CAFFEIC ACID

SynDRA canonical compound SYN0001624 — structure-anchored drug synonym record

Clinical phase	Preclinical
Primary target(s)	ALOX5 \| MIF \| TNF
Mechanism of action	HIV integrase inhibitor \| lipoxygenase inhibitor \| nitric oxide production inhibitor \| tumor necrosis factor production inhibitor

All known targets

ALOX5
MIF
TNF

Mechanisms of action (all sources)

HIV integrase INHIBITOR
lipoxygenase inhibitor
nitric oxide production inhibitor
tumor necrosis factor production inhibitor
MIF INHIBITOR
ALOX5 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Cross-references

PubChem CID: 689043
ChEMBL: CHEMBL145
DrugBank: DB01880
ChEBI: 16433
KEGG: C01197
RxNorm: 1311397
PDB: DHC
Wikipedia: Caffeic_acid
TTD: D0V9EN

Synonyms

Cinnamic acid, 3,4-dihydroxy-
Trans-3,4-dihydroxycinnamic acid
Trans-caffeate
Trans-caffeic acid
2-PROPENOIC ACID, 3-(3,4-DIHYDROXYPHENYL)-, (2E)-
NSC-57197
NSC-623438
3,4-Dihydroxycinnamic Acid
3-(3,4-dihydroxyphenyl)acrylic acid
(E)-3-(3,4-dihydroxyphenyl)acrylic acid
3,4-Dihydroxybenzeneacrylic acid
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
trans-caffeic acid
trans-Caffeate
3,4-Dihydroxy-trans-cinnamate
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-
3-(3,4-Dihydroxyphenyl)propenoic acid
UNII-U2S3A33KVM
3-(3,4-Dihydroxyphenyl)-2-propenoic acid
4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
caffeic acid (constituent of black cohosh)
U2S3A33KVM
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, (2E)-
caffeic acid (iarc)
Trans 3,4-Dihydroxycinnamic acid
3,4-Dihydroxycinnamic acid
(E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
4-(2'-Carboxyvinyl)-1,2-dihydroxybenzene
CHEBI:36281
NSC57197
DTXCID10231
CHEBI:16433
NSC623438
CHEBI:17395
Caffeic Acid 1507
caffeic acid, (E)-
RefChem:6400
(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

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