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LOPINAVIR
SynDRA canonical compound SYN0001612 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Mechanism of action | HIV protease inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- ABCB1
- ABCG2
- HIV-1 protease
- KCNH2
- Zmpste24
- gag-pol
- pol
- protease
Mechanisms of action (all sources)
- protease inhibitor
- pol INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TBXA2R
- PGR
- ADRA1A
- ESR1
- HTR2B
- CYP3A4
- ALB
- ABCB11
- MAOA
- NPY2R
- NPY1R
- MLNR
- MC4R
- MC3R
- HTR3A
- KDR
- ICMT
- NTSR1
- HTR2C
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- NR3C1
- OPRM1
- OPRD1
- SLC6A3
- TDP1
- TACR1
- SMAD3
- SLCO2B1
- SLCO1B3
- SLCO1B1
- SLCO1A2
- SLC6A4
- SLC6A2
- OPRK1
- SLC29A1
- SCN5A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- ATXN2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- ESRRA
- FUS
- GCR
- GLI3
- KSYK
- NF2L2
- NR1I2
- SMAD2
- SYK
Drug classes
- HIV Protease Inhibitors
- Protease Inhibitor
- P-Glycoprotein Inhibitors
- Organic Anion Transporting Polypeptide 1B1 Inhibitors
- Cytochrome P450 3A Inhibitors
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antiviral Agents
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
ATC classes
Cross-references
Synonyms
- KALETRA
- Kaletra
- LOPINAVIR AND RITONAVIR
- aluviran
- koletra
- Lopinavir-
- Aluviran
- Koletra
- Lopinavir, (s-(2s,4s,5s))-
- Lopinavirum
- A-157378-0
- A-157378.0
- ABT-378
- Lopinavir component of kaletra
- AIDS032937
- Aluvia (TN)
- Kaletra (TN)
- LPV
- Lopinavir (JAN/USAN/INN)
- Lopinavir [USAN:INN:BAN]
- RS-346
- A 157378
- ABT 157378
- ABT 378
- CHEBI:31781
- ABT378
- DTXCID6026456
- RefChem:5960
- ABT-378/r
- A157378.0
- J05AE06
- MFCD22628840
- NCGC00164576-02
- C37H48N4O5
- SMR002529581
- CAS-192725-17-0
- MFCD22373646
- Lopinavir?
Reported adverse events
- Pancreatitis
- Rash
- Amylase
- Dysgeusia
- Hepatotoxicity
- Bradyarrhythmia
- Toxic epidermal necrolysis
- Stevens-Johnson syndrome
- Abnormal dreams
- Headache
- Hypertension
- Myalgia
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