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PROCHLORPERAZINE
SynDRA canonical compound SYN0001611 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DRD2 |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
| Indication | nausea | vomiting |
|---|
| Disease area | gastroenterology |
|---|
All known targets
- DRD2
- DRD4
- DRD3
- DRD1
- ADRA1A
- HTR1A
- HTR2B
- HTR2C
- HTR4
- HTR6
- Htr1a
- Htr1b
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- DRD1 ANTAGONIST
- DRD3 ANTAGONIST
- DRD4 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- MC3R
- MC4R
- ESR2
- OPRK1
- OPRD1
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- MMP1
- NFKB1
- NFE2L2
- OPRM1
- MTOR
- MPHOSPH8
- MMP9
- NPSR1
- MLNR
- PDE4D
- MCL1
- MC5R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- L3MBTL1
- KDM4E
- KDM4A
- PDE3A
- ABCB1
- IDH1
- SLCO1B3
- VDR
- USP2
- USP1
- UBE2N
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- MDM4
- MDR1
- MLLT3
- NCF1
- NPR2
- NTM1A
- OXYR
- PAFA
- PPCEL
- RAPGEF3
- RARA
- RGAP1
- RPGF3
- RPGF4
- SMAD2
- MDM2
- M4K2
- KCNJ1
- CP2CJ
- AHR
- ALR
- APAF
- CAC1H
- CP19A
- CP1A2
- CP2D6
- JUN
- CP3A7
- ESRRA
- GEMI
- GLI3
- IDHC
- IL1B
- STK33
Drug classes
- Antiemetics
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Gastrointestinal Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Tranquilizing Agents
- Phenothiazine
ATC classes
Cross-references
Synonyms
- COMPAZINE
- COMPRO
- Compazine
- Compro
- PROCHLORPERAZINE EDISYLATE
- PROCHLORPERAZINE MALEATE
- PROCOMP
- prochlorperazine mesylate
- capazine
- chlormeprazine
- chlorperazine
- meterazin
- meterazine
- proazine
- prochlorpemazine
- prochlorperazin
- prochlorpromazine
- prochlorperazine maleate
- prochlorperazine edisylate
- prochlorperazine dimaleate
- prochlorperzine
- Prochlorperazine mesilate
- Proclorperazina
- Prochlorperazine mesylate
- Stemetil eff
- CHLOPERAZINE
- Capazine
- Chlormeprazine
- Chlorperazine
- Combid
- Emelent
- Eskatrol
- Kronocin
- Meterazin
- Meterazine
- Nipodal
- Novamin
Reported adverse events
- Dyskinesia
- Dystonia
- Leukopenia
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