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THIOGUANINE
SynDRA canonical compound SYN0001600 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | IMPDH2 |
|---|
| Mechanism of action | Purine antagonist |
|---|
| Indication | acute myeloid leukemia (AML) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- IMPDH1
- IMPDH2
- ABCC4
- ABCC5
- ADORA3
- ALOX15
- HPRT1
- MAPK3
- PTGS1
- REP
- XDH
- folK
Mechanisms of action (all sources)
- Purine antagonist
- IMPDH1 INHIBITOR
- Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor
- IMPDH2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ACHE
- LCK
- NR3C1
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK14
- MAPK1
- MAOA
- KDM4A
- OPRK1
- KCNH2
- IDH1
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HPGD
- HMGCR
- OPRD1
- OPRM1
- HBB
- PAK1
- USP2
- TP53
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- AHR
- SYK
- RARA
- PHGDH
- NTMT1
- NTM1A
- NSD2
- NF2L2
- MITF
- MDR1
- KSYK
- ITA4
- IFNG
- IDHC
- GLI3
- GCR
- ESRRA
- CP3A7
- CP2CJ
- CP2C9
- CP1A2
- CP19A
- ATF6
- ANDR
- TR10B
Drug classes
- Antimetabolites
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Noxae
ATC classes
Cross-references
Synonyms
- Tabloid
- 6-Thioguanine
- tioguanine
- Tioguanine
- Tioguanina
- Thioguanine anhydrous
- Thioguanine hemihydrate
- Thioguanine, anhydrous
- Tioguanine hemihydrate
- NSC-752
- NSC-76504
- Lanvis
- 6 Thioguanine
- THG
- ThioguaninGSK
- Tioguanin
- Tioguaninum
- Glaxo Wellcome Brand of Thioguanine
- Glaxo Wellcome Brand of Tioguanine
- GlaxoSmithKline Brand of Thioguanine
- GlaxoSmithKline Brand of Tioguanine
- Thioguanin-GSK
- Thioguanine Hemihydrate
- Thioguanine Monosodium Salt
- Thioguanine Tabloid
- Tioguanina Wellcome
- Tioguanine GlaxoSmithKline Brand
- Wellcome Brand of Thioguanine
- BW 5071
- DX4
- LT00455187
- Wellcome U3B
- Lanvis (TN)
- Thioguanine [USAN:BAN]
- Tioguanina[INN-Spanish]
- Tioguanine (INN)
- Tioguaninum [INN-Latin]
- Purine antimetabolite: antimetabolite: inhibits nucleic acid replication
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