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FLUPHENAZINE
SynDRA canonical compound SYN0001598 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DRD2 |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- DRD1
- HTR2A
- HTR7
- HTR6
- HRH1
- DRD5
- HTR1B
- HTR2B
- Htr7
- HTR1E
- HTR2C
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR2A ANTAGONIST
- HTR6 INVERSE AGONIST
- HTR7 INVERSE AGONIST
- DRD1 ANTAGONIST
- DRD5 ANTAGONIST
- HRH1 ANTAGONIST
- HTR1B MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- HDAC6
- ADRB2
- MPHOSPH8
- PGR
- PDE5A
- PDE4D
- PDE3A
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- NPSR1
- NOX1
- NFKB1
- MTOR
- MMP1
- MMP9
- PPP3CA
- MLNR
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDM4A
- PMP22
- PRKCA
- HTR3A
- SLCO1B3
- USP2
- USP1
- UGT1A4
- UBE2N
- TP53
- THPO
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- 5HT6R
- KCMB2
- KCMB4
- KSYK
- M4K2
- MDM2
- MDM4
- MDR1
- MMP14
- NNMT
- NSD2
- NTM1A
- NTMT1
- PAFA
- PNMT
- RARA
- RPGF4
- STK33
- SYK
- TLR3
- KCMB1
- KCMA1
- JUN
- CP1A2
- 5HT7R
- ACM1
- ALR
- ANDR
- APAF
- CASP3
- CASP7
- COMT
- CP2D6
- IL1B
- CP3A4
- CP3A7
- GAMT
- GEMI
- GNMT
Drug classes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Tranquilizing Agents
- Phenothiazine
ATC classes
Cross-references
Synonyms
- FLUPHENAZINE HYDROCHLORIDE
- PERMITIL
- PROLIXIN
- fluorfenazine
- fluorophenazine
- fluorphenazine
- ftorphenazine
- phthorphenazine
- fluphenazine hydrochloride
- fluphenazine dihydrochloride
- fluphenazine HCl
- flufenazin
- Flufenazina
- NSC-62323
- Triflumethazine
- Fluorophenazine
- Fluorphenazine
- Fluorfenazine
- Siqualon
- Elinol
- Phthorphenazine
- Vespazine
- Ftorphenazine
- Siqualine
- Sevinol
- Pacinol
- Fluphenazinum
- Prolixin
- Flufenazin
- Dapotum
- Flufenazina [DCIT]
- Yespazine
- SQ 4918
- Fluphenazine [INN:BAN]
- Moditen (Tabl or elixir)
- Fluphenazinum [INN-Latin]
- 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine
- UNII-S79426A41Z
Reported adverse events
- Dyskinesia
- Hypotension
- Skin disorder
- Dystonia
- Hypertension
- Muscle rigidity
- Leukocytosis
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