ZOTEPINE

SynDRA canonical compound SYN0001545 — structure-anchored drug synonym record

Clinical phase	Launched
Primary target(s)	ADRA2B \| DRD2 \| DRD3 \| DRD4 \| HRH1 \| HTR1A \| HTR1B \| HTR1D \| HTR1E \| HTR2A \| HTR2C \| HTR6 \| HTR7 \| SLC6A2 \| SLC6A4
Mechanism of action	dopamine receptor antagonist \| serotonin receptor antagonist
Indication	schizophrenia
Disease area	neurology/psychiatry

All known targets

HTR2A
HRH1
DRD2
SLC6A2
HTR7
HTR6
HTR2C
HTR1E
HTR1D
HTR1B
HTR1A
DRD4

Mechanisms of action (all sources)

HTR1A ANTAGONIST
HTR1B ANTAGONIST
HTR1D ANTAGONIST
HTR1E ANTAGONIST
HTR2A ANTAGONIST
HTR2C INVERSE AGONIST
HTR6 INVERSE AGONIST
HTR7 INVERSE AGONIST
ADRA2B ANTAGONIST
DRD2 ANTAGONIST
DRD3 ANTAGONIST
DRD4 ANTAGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

5HT1A
5HT1B
SC6A4
SC6A2
RARA
NSD2
KSYK
JUN
GPR151
GLI3
CP3A4
CP2D6
CP1A2
ANDR
ADRA1D
ADA2B
ACM1
5HT7R
5HT6R
5HT2C
5HT2A
5HT1E
5HT1D
SYK

Drug classes

Antipsychotic Agents
Central Nervous System Agents
Central Nervous System Depressants
Psychotropic Drugs
Tranquilizing Agents

ATC classes

N05A · ANTIPSYCHOTICS

Cross-references

PubChem CID: 5736
ChEMBL: CHEMBL285802
DrugBank: DB09225
ChEBI: CHEBI:32316
KEGG: D01321
RxNorm: 40003
PDB: ZOT
Wikipedia: Zotepine
TTD: D0T6QX

Synonyms

Look up ZOTEPINE in the interactive SynDRA portal →