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QUETIAPINE
SynDRA canonical compound SYN0001544 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR2A |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | bipolar disorder | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2A
- HTR1D
- HTR1E
- HRH1
- HTR1A
- HTR2C
- SLC6A2
- HTR1F
- DRD1
- HTR1B
- HTR6
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR1A FULL AGONIST
- HTR1D FULL AGONIST
- HTR1E FULL AGONIST
- HTR1F FULL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- OPRM1
- HRH2
- ESR1
- MAPK3
- NR3C1
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK14
- OPRD1
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- KDM4E
- KAT2A
- HRH3
- HMGCR
- NTSR1
- ABCB1
- GMNN
- PDE3A
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC29A1
- SCN5A
- SAMHD1
- RAPGEF3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT1D
- 5HT1E
- 5HT1F
- ACM1
- ACM4
- CP2D6
- CP3A4
- ESRRA
- KCMA1
- KCMB1
- KCMB2
- KCMB4
- NR1I2
- PLIN5
- SC6A2
Drug classes
- Atypical Antipsychotic
- Antidepressive Agents
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Psychotropic Drugs
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- QUETIAPINE FUMARATE
- SEROQUEL
- SEROQUEL XR
- Seroquel
- quetiapine fumarate
- quetiapine hemifumarate
- ICI 204,636
- seroquel
- Quetiapina
- Norsic
- Quetiapine extended release
- NSC-758918
- Atrolak xl
- Biquelle xl
- Brancico xl
- Ebesque xl
- Mintreleq xl
- Psyquet xl
- Seotiapim xl
- Seroquel xl
- Sondate xl
- Tenprolide xl
- Zaluron xl
- Quetiapine [INN:BAN]
- UNII-BGL0JSY5SI
- BGL0JSY5SI
- CHEMBL716
- CHEBI:8707
- C21H25N3O2S
- URKOMYMAXPYINW-UHFFFAOYSA-N
- NCGC00095911-03
- Co-Quetiapine
- Quetiapinum
- Quetiapine hemifumarate
- Ketipinor (TN)
- Norsic (TN)
- Quetiapine (INN)
- Seroquel (Fumarate)
Reported adverse events
- GH
- Elderly
- Somnolence
- Irritability
- Vomiting
- Agranulocytosis
- Akathisia
- Constipation
- Depression
- Dyskinesia
- Dysphagia
- Hypotension
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