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OLANZAPINE
SynDRA canonical compound SYN0001543 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
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| Primary target(s) | HTR7 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | bipolar disorder | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2A
- DRD4
- HTR2C
- DRD3
- HTR1B
- HTR1D
- HTR1E
- HTR1A
- HTR6
- HTR7
- HRH1
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- DRD2 ANTAGONIST
- D2-like dopamine receptor antagonist
- DRD3 ANTAGONIST
- DRD4 ANTAGONIST
- DRD2 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- PTGS2
- RARG
- PDE5A
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- NTSR1
- NR3C1
- NR1I3
- NR1I2
- NR1H4
- NR1H3
- NR1H2
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- PDE4D
- PGR
- PDE6A
- ABCB11
- VDR
- USP2
- UGT1A4
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- DAO
- RGS4
- NSD2
- LYAG
- KSYK
- KCMB4
- KCMA1
- HTR3E
- HTR3D
- HTR3C
- HTR3B
- GPX1
- CP3A7
- 5HT1B
- CFTR
- ALR
- ALAT2
- ACM5
- ACM4
- ACM1
- 5HT7R
- 5HT6R
- 5HT1F
- 5HT1E
- 5HT1D
- SYK
Drug classes
- Atypical Antipsychotic
- Antiemetics
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Gastrointestinal Agents
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Selective Serotonin Reuptake Inhibitors
ATC classes
Cross-references
Synonyms
- LYBALVI
- Lybalvi
- OLANZAPINE AND FLUOXETINE HYDROCHLORIDE
- SYMBYAX
- ZYPREXA
- ZYPREXA RELPREVV
- ZYPREXA ZYDIS
- Zyprexa
- olanzapine pamoate
- olanzapine embonate
- zyprexa relprevv
- olanzapine pamoate monohydrate
- zyprexa
- LY-170053
- Olanzapina
- Olansek
- Olanzapine apotex
- Olanzapine cipla
- Olanzapine glenmark
- Olanzapine mylan
- Olanzapine teva
- Olazax
- Olazax disperzi
- Zyprexa velotab
- LY170053
- Arkolamyl
- Olanzapine cipla (previously olanzapine neopharma)
- Olanzapine component of lybalvi
- Olanzapine component of symbyax
- Olanzapine glenmark europe
- Zalasta
- Zyprexa zydis
- Lanzac
- Midax
- Olanzapinum
- Symbyax
- Zydis
Reported adverse events
- Sedation
- Delirium
- Parkinsonism
- Speech disorder
- Seizure
- Somnolence
- Dizziness
- Dyskinesia
- Fatigue
- Dry mouth
- Asthenia
- Arthralgia
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