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ZIPRASIDONE
SynDRA canonical compound SYN0001524 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR7 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | bipolar disorder | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2C
- HTR2A
- HTR7
- HTR1E
- HTR1D
- HTR1B
- HTR1A
- HRH1
- SLC6A4
- HTR6
- HTR3A
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR1A PARTIAL AGONIST
- HTR1B FULL AGONIST
- HTR1D FULL AGONIST
- HTR1E FULL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- OPRM1
- ADORA3
- MLNR
- NPY2R
- NPY1R
- MTOR
- MTARC2
- MTARC1
- MC4R
- NTSR1
- MC3R
- MAPT
- MAOA
- KDR
- HSPA5
- HRH3
- NR3C1
- ABCB1
- OPRD1
- HCAR2
- PDE3A
- PDE4A
- PDE4D
- PGR
- PTGS1
- PTGS2
- RAB9A
- RGS4
- SCN5A
- SLC29A1
- TBXA2R
- TDP1
- USP1
- HDAC6
- GIPR
- ABCB11
- ATAD5
- BDKRB2
- BDKRB1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- GLI3
- SYK
- SC6A4
- RXFP1
- NTM1A
- NSD2
- KSYK
- IFNG
- HTR3E
- HTR3D
- HTR3C
- HTR3B
- GPX4
- GCR
- 5HT1B
- ESRRA
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- ANDR
- AHR
- ACM1
- 5HT7R
- 5HT1E
- 5HT1D
- TP53
Drug classes
- Atypical Antipsychotic
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Serotonin Agents
- Serotonin Antagonists
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- GEODON
- Geodon
- ZIPRASIDONE HYDROCHLORIDE
- ZIPRASIDONE MESYLATE
- zaprasidone
- ziprasidone hydrochloride
- ziprasidone mesylate
- geodon
- ziprasidone HCl
- ziprasidone mesilate
- Ziprasidona
- Zipradon
- CP-88059
- Zeldox
- Ziprasidone hydrochloride
- Ziprasidone [INN:BAN]
- UNII-6UKA5VEJ6X
- CP 88059
- Ziprasidone mesylate trihydrate
- 6UKA5VEJ6X
- CHEMBL708
- C21H21ClN4OS
- CHEBI:10119
- CP-88,059-1
- ziprazidone
- DSSTox_CID_3753
- DSSTox_RID_77186
- DSSTox_GSID_23753
- ziprasidonum
- ziprasidona
- CP 88059-01
- Geodon (TN)
- Zeldox (TN)
- Zipradon (TN)
- Ziprasidone (INN)
- CP-88,059
- CP-88059-1
- CP-88,059-01
Reported adverse events
- Agranulocytosis
- Akathisia
- Asthenia
- Dizziness
- Dyskinesia
- Dystonia
- Enuresis
- Hypotension
- Insomnia
- Leukopenia
- Neutropenia
- Priapism
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