← SynDRA
TAMIBAROTENE
SynDRA canonical compound SYN0001519 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | RARB |
|---|
| Mechanism of action | Retinoid receptor agonist |
|---|
| Indication | acute promyelocytic leukemia (APL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
Mechanisms of action (all sources)
- Retinoid receptor agonist
- RARB AGONIST
- Retinoic acid receptor beta agonist
- RARA AGONIST
- Retinoic acid receptor alpha agonist
- RARG AGONIST
- RARB MODULATOR
- RARA MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TBXA2R
- ESR1
- RXRA
- ACHE
- RXRB
- NR5A1
- NTHL1
- OGG1
- OPRM1
- PDE3A
- PDE4A
- PGR
- PTGS1
- SLC6A2
- RXRG
- NR2E1
- SLC6A3
- SLC6A4
- SMUG1
- TDG
- TDP1
- TOP2A
- UNG
- USP1
- NR4A1
- NR2C1
- ADORA3
- F2
- ADRA1A
- ADRA2A
- AR
- CHRM1
- CHRM2
- CYP26A1
- CYP3A4
- DRD1
- DRD3
- HDAC6
- NEIL2
- HNF4A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP19A
- CP3A7
- DRD2
- ESR2
- ESRRA
- GPX4
- NR1H4
- PRGR
Cross-references
Synonyms
- amnolake
- Am80
- Tamibaroteno
- Amnoid
- SY-1425
- AM-80
- INNO-507
- NSC-608000
- OP-01
- RR-110
- TM-411
- TOS-80T
- Tamibarotene (oral, Alzheimer's disease)
- OPI-1100
- OP-01 program (prodrug, solid tumor), Onco-Pharmakon
- 4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid
- retinobenzoic acid
- Amnolake
- Tamibaro
- 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
- 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid
- Tamibarotene(Am-80)
- 4-((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl)benzoic acid
- CHEMBL25202
- CHEBI:32181
- 08V52GZ3H9
- NSC608000
- Benzoic acid, 4-(((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino)carbonyl)-
- NCGC00181111-01
- 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
- SMR002530320
- CAS-94497-51-5
- Tamibarotene [INN]
- Amnoleuk
- UNII-08V52GZ3H9
- 2cbr
- 4-(((5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)AMINO)CARBONYL)BENZOIC ACID
- A80
Look up TAMIBAROTENE in the interactive SynDRA portal →