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DOXAZOSIN
SynDRA canonical compound SYN0001511 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA1A |
|---|
| Mechanism of action | Adrenergic receptor antagonist |
|---|
| Indication | benign prostatic hyperplasia (BPH) | hypertension |
|---|
| Disease area | cardiology | urology |
|---|
All known targets
- ADRA1D
- ADRA1B
- ADRA1A
- ABCB1
- HTR2B
- SLC6A3
- MMP1
- KCNH2
- HTR4
- HTR2C
- CYP2C19
- HLA-A
Mechanisms of action (all sources)
- Adrenergic receptor antagonist
- ADRA1A ANTAGONIST
- Adrenergic receptor alpha-1 antagonist
- ADRA1D ANTAGONIST
- ADRA1B ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH2
- TACR1
- HTR2A
- SLC6A2
- CHRM1
- CHRM2
- OPRM1
- DRD1
- OPRK1
- ADRA2B
- ABCC4
- MC5R
- MAOA
- MLNR
- MC4R
- MMP9
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- ABCB11
- KDM4E
- LMNA
- LCK
- KDR
- NPY1R
- IDH1
- HTR6
- HTR3A
- HTR1A
- HRH3
- HRH1
- HPGD
- HMGCR
- HDAC6
- GMNN
- GLA
- MTOR
- OPRD1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- KCMB4
- NTM1A
- NR1I2
- MDR1
- M4K2
- LYAM2
- LYAG
- KCMB2
- ACM4
- KCMB1
- KCMA1
- GPX1
- GPR32
- GLI3
- GEMI
- TSHR
Drug classes
- Adrenergic alpha-Antagonists
- alpha-Adrenergic Blocker
- Adrenergic Agents
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic Antagonists
- Antihypertensive Agents
- Cardiovascular Agents
- Neurotransmitter Agents
ATC classes
- C02C · ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
- DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Cross-references
Synonyms
- CARDURA
- CARDURA XL
- Cardura
- DOXAZOSIN MESYLATE
- doxazosin mesylate
- doxazosine
- doxazosin mesilate
- Doxazosine
- Doxazosina
- C02CA04
- UK-33274
- Doxazosinum
- Normothen
- Doxazosina [Spanish]
- Doxazosine [French]
- Doxazosinum [Latin]
- Cardura (TN)
- Cardura XL (TN)
- Cardura-1
- Cardura-2
- Cardura-4
- Carduran (TN)
- Doxazosin (INN)
- Doxazosin [INN:BAN]
- (+-)-doxazosin
- UK 33274
- Cardura XL
- NW1291F1W8
- CHEBI:4708
- ratio-Doxazosin
- DoxaUro
- Doxazosin Wolff
- Novo Doxazosin
- Apo Doxazosin
- Gen Doxazosin
- Doxa Puren
- MTW Doxazosin
- Neo, Carduran
Reported adverse events
- Dizziness
- Fatigue
- Hypotension
- Malaise
- Polyuria
- Rhinitis
- Somnolence
- Leukopenia
- Neutropenia
- Dyspnoea
- Oedema
- Pain
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