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MESALAMINE
SynDRA canonical compound SYN0001504 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Prostanoid receptor antagonist |
|---|
| Indication | inflammatory bowel disease | ulcerative colitis |
|---|
| Disease area | gastroenterology |
|---|
All known targets
- PPARG
- PTGS1
- ALOX5
- PTGS2
- CHUK
- CTNNB1
- Hao1
- IKBKB
- MPO
- NAT1
- TNF
- IFNG
Mechanisms of action (all sources)
- Lipoxygenase inhibitor
- Cyclooxygenase inhibitor
- Prostanoid receptor antagonist
- ALOX5 INHIBITOR
- Arachidonate 5-lipoxygenase inhibitor
- PPARG AGONIST
- Peroxisome proliferator-activated receptor gamma agonist
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- PPARG FULL AGONIST
- ABCG2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TST
- ESR1
- ABCC2
- SLC26A4
- KAT2A
- KCNH2
- KDM4E
- KDR
- MAOA
- OPRM1
- PDE3A
- PDE4A
- PGR
- POLK
- RECQL
- SAMHD1
- SLC6A2
- HTR1A
- SLC6A3
- SLC6A4
- SLCO1A2
- SLCO1B1
- SLCO1B3
- SLCO2B1
- TBXA2R
- TDP1
- THRB
- UGT1A6
- UGT1A9
- USP1
- HTR2B
- HSD17B10
- ACHE
- HRH3
- ADORA3
- ADRA1A
- ADRA2A
- ALDH1A1
- ALOX15
- APEX1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- B2CL1
- NTM1A
- UBP1
- PPM1D
- PHGDH
- PAFA
- PADI4
- NUDT15
- NTMT1
- MITF
- CP2C9
- MCL1
- ITA4
- GSTO1
- GLSK
- G3P
- CP3A4
- CP2CJ
- UNG
Drug classes
- Aminosalicylate
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Gastrointestinal Agents
- Anti-Infective Agents
ATC classes
- A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
Cross-references
Synonyms
- APRISO
- ASACOL
- ASACOL HD
- Apriso
- CANASA
- Canasa
- DELZICOL
- Delzicol
- LIALDA
- Lialda
- PENTASA
- mesalazine
- 5-ASA
- 2-Hydroxy-5-aminobenzoic acid
- 3-Carboxy-4-hydroxyaniline
- 5-Amino-2-hydroxybenzoic acid
- 5-Aminosalicylic acid
- claversal
- mesacol
- mesalsal
- mesasal
- m-Aminosalicylic acid
- mesalamine hydrochloride
- mesalamine HCl
- Mesalazine
- Mesalazina
- Benzoic acid, 5-amino-2-hydroxy-
- Fisalamine
- Iialda
- MAX-002
- NSC-38877
- Asacol
- Asacol hd
- Coltec ec
- Ipocol
- Mesren mr
- Mezavant xl
Reported adverse events
- Hypersensitivity
- Rash
- Renal impairment
- Stevens-Johnson syndrome
- Nephrolithiasis
- Flatulence
- Severe cutaneous adverse reaction
- Headache
- Dizziness
- Abdominal pain
- Alopecia
- Dyspepsia
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