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BACLOFEN
SynDRA canonical compound SYN0001489 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GABBR2 |
|---|
| Mechanism of action | GABA receptor agonist |
|---|
| Indication | multiple sclerosis | spasms |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- GABBR2
- GABBR1
- KCTD8
- KCTD16
- KCTD12
- Gabrb3
- Gabrq
- Gabrp
- Gabrg3
- Gabrg2
- Gabrg1
- Gabre
Mechanisms of action (all sources)
- GABA receptor agonist
- GABBR1 AGONIST
- GABA-B receptor agonist
- GABBR2 AGONIST
- GABBR1 FULL AGONIST
- GABBR2 FULL AGONIST
- KCTD8 FULL AGONIST
- KCTD12 FULL AGONIST
- KCTD16 FULL AGONIST
- benzodiazepine receptor agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- LCK
- NPY1R
- NFKB1
- NFE2L2
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- KDR
- NR1I2
- KCNH2
- KAT2A
- HTR7
- HTR6
- HTR5A
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- NPY2R
- NR3C1
- ADORA1
- PTPRC
- TBXAS1
- TBXA2R
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- GABA B Agonists
- GABA A Agonists
- Central Nervous System Agents
- GABA Agents
- GABA Agonists
- GABA-B Receptor Agonists
- Muscle Relaxants, Central
- Neuromuscular Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- gamma-Aminobutyric Acid-ergic Agonist
ATC classes
- M03B · MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Cross-references
Synonyms
- FLEQSUVY
- Fleqsuvy
- GABLOFEN
- Gablofen
- KEMSTRO
- LIORESAL
- LYVISPAH
- Lioresal
- Lyvispah
- OZOBAX
- OZOBAX DS
- baclon
- lioresal
- DL-Baclofen
- Baclofene
- Baclofeno
- (rs)-baclofen
- BA-34,647
- BA-34647
- NSC-755906
- Baclospas-10
- Kemstro
- Lioresal intrath
- Lyflex
- Ozobax ds
- Arbaclofen
- (R)-Baclofen
- d-Baclofen
- (-)-Baclofen
- (R)-(-)-Baclofen
- R-Baclofen
- R-(-)-Baclofen
- STX209
- UNII-NYU6UTW25B
- l-Baclofen
- STX 209
- NYU6UTW25B
Reported adverse events
- Nausea
- Hypotension
- Sedation
- Constipation
- Headache
- Insomnia
- Dizziness
- Epilepsy
- Fatigue
- Schizophrenia
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