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TETRACAINE
SynDRA canonical compound SYN0001471 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SCN10A |
|---|
| Mechanism of action | Membrane integrity inhibitor |
|---|
| Indication | anesthetic |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SCN9A
- SCN10A
- SCN1A
- SCN2A
- SCN3A
- SCN5A
- SCN7A
- SCN8A
- SCN4A
- SCN11A
- Scn2a
- Scn1a
Mechanisms of action (all sources)
- Membrane integrity inhibitor
- SCN1A BLOCKER
- Sodium channel alpha subunit blocker
- SCN5A BLOCKER
- SCN4A BLOCKER
- SCN7A BLOCKER
- SCN2A BLOCKER
- SCN9A BLOCKER
- SCN3A BLOCKER
- SCN11A BLOCKER
- SCN8A BLOCKER
- SCN10A BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- NTSR1
- CNR1
- HRH1
- HRH2
- HTR2B
- DRD4
- MAPK14
- LCK
- LMNA
- MAOB
- MAPK1
- MC3R
- MAPK3
- KCNH2
- MC4R
- MC5R
- MLNR
- MMP1
- KDM4E
- HTR7
- KAT2A
- NPY1R
- HTR6
- HTR5A
- HTR3A
- HTR1A
- HSPA5
- HRH3
- HMGCR
- HDAC6
- GMNN
- GIPR
- GHSR
- GCGR
- MMP9
- ABCB1
- GBA1
- SLCO1B1
- RGS4
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Anesthetics
- Anesthetics, Local
- Central Nervous System Agents
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Sensory System Agents
- Ester Local Anesthetic
ATC classes
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- D04A · ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
- S01H · LOCAL ANESTHETICS
- N01B · ANESTHETICS, LOCAL
Cross-references
Synonyms
- KOVANAZE
- Kovanaze
- PLIAGLIS
- Pontocaine
- SYNERA
- TETRACAINE HYDROCHLORIDE
- tetracaine monohydrochloride
- pontocaine
- amethocaine
- laudocaine
- tetracaine hydrochloride
- tetracaine HCl
- Tetracaina
- Ametop
- Dicaine
- Tetracaine component of pliaglis
- Tetracaine component of synera
- Amethocaine
- Anetain
- Contralgin
- Dicain
- Dikain
- Fissucain
- Intercain
- Laudocaine
- Medicaine
- Meethobalm
- Metraspray
- Mucaesthin
- Niphanoid
- Rexocaine
- Tetracainum
- Tetrakain
- Uromucaesthin
- Tetrakain [Czech]
- Amethocaine (TN)
- Diaethylaminoaethanol ester der p-butylaminobenzoesaeure;Diaethylaminoaethanol ester der p-butylaminobenzoesaeure [German]
- Medihaler-Tetracaine
Reported adverse events
- Bradycardia
- Dizziness
- Dysgeusia
- Dysphagia
- Epistaxis
- Headache
- Hypertension
- Lacrimation increased
- Nasal congestion
- Sinus headache
- Sneezing
- Rhinalgia
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