← SynDRA

DALFAMPRIDINE

SynDRA canonical compound SYN0001447 — structure-anchored drug synonym record

All known targets

• KCND1
• KCNB2
• KCNA10
• KCNA5
• KCND3
• KCND2
• KCNC3
• KCNC2
• KCNC1
• KCNA1
• KCNB1
• KCNA6

Mechanisms of action (all sources)

• Potassium channel blocker
• KCNQ1 BLOCKER
• Voltage-gated potassium channel blocker
• KCND3 BLOCKER
• KCNH2 BLOCKER
• KCNA2 BLOCKER
• KCNA1 BLOCKER
• KCNQ2 BLOCKER
• KCNQ3 BLOCKER
• KCNA7 BLOCKER
• KCNQ5 BLOCKER
• KCNQ4 BLOCKER

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ACHE
• PGR
• HTR2B
• IDH1
• LMNA
• MAOA
• MAPK1
• MAPT
• NR3C1
• OPRM1
• PDE3A
• PDE4A
• PTGS1
• ADORA3
• RAPGEF3
• SAMHD1
• SLC47A1
• SLC47A2
• SLC6A2
• SLC6A3
• SLC6A4
• SMN1
• TBXA2R
• TSHR
• HTR1A
• HRH3
• HDAC6
• GMNN
• ADRA1A
• ADRA2A
• ALDH1A1
• APEX1
• AR
• CBX1
• CHRM1
• CHRM2
• CYP1A2
• CYP2C19
• CYP2C9
• CYP2D6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• COMT
• CP2D6
• GAMT
• GNMT
• HNMT
• KCJ13
• NNMT
• PNMT

Drug classes

• Potassium Channel Antagonists
• Potassium Channel Blocker
• Cardiovascular Agents
• Membrane Transport Modulators
• Potassium Channel Blockers

ATC classes

• N07X · OTHER NERVOUS SYSTEM DRUGS

Cross-references

• PubChem CID: 1727
• ChEMBL: CHEMBL284348
• DrugBank: DB06637
• ChEBI: CHEBI:34385
• KEGG: D04127
• RxNorm: 897018
• Wikipedia: 4-Aminopyridine
• TTD: D08YIN
• LINCS BRD: BRD-K22482860

Synonyms

• AMPYRA
• Ampyra
• fampridine
• fampyra
• ampyra
• pyridin-4-amine
• 4-aminopyridine
• Fampridine
• Fampridina
• Fampridine (4-aminopyridine)
• EL-970
• NSC-15041
• Ampyra extended release
• Fampridine accord
• Fampyra
• Ampyra (TN)
• 4-Pyridinamine
• dalfampridine (ii)
• FAMPYRA
• BH3B64OKL9
• dalfampridine (usp monograph)
• 4-Aminopyridine
• 4 AP
• dalfampridine (usp-rs)
• NSC 15041
• 4-Pyridylamine
• Avitrol
• p-Aminopyridine
• gamma-Aminopyridine
• Amino-4 pyridine
• Avitrol 200
• Phillips 1861
• Neurelan
• Fampridine SR
• fampridina
• VMI-10-3
• Mi-W-3