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ETHINYL ESTRADIOL
SynDRA canonical compound SYN0001446 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP2C8 | ESR1 | ESR2 | NR1I2 |
|---|
| Mechanism of action | estrogenic hormone | estrogen receptor agonist |
|---|
| Indication | contraceptive |
|---|
| Disease area | endocrinology |
|---|
All known targets
- ESR1
- ESR2
- ADORA2A
- OPRK1
- SLC6A3
- SLC6A2
- SLC47A2
- SLC47A1
- SLC36A1
- SLC22A2
- SHBG
- PGR
Mechanisms of action (all sources)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- CYP2B6
- CASP1
- UGT1A1
- RARA
- NR1H4
- SULT1A1
- HTR1A
- NTSR1
- OPRD1
- PDE3A
- MC5R
- NR1H2
- PDE4A
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- NR1H3
- MC4R
- PDE5A
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KCNH2
- HTR7
- HTR6
- HTR5A
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- PDE4D
- ABCB1
- PPARA
- HSD17B7
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- NTMT1
- KSYK
- LRC26
- MDR1
- NLRP1
- NSD2
- NTM1A
- PPARD
- ANDR
- PRGR
- RORC
- SMAD2
- SMAD3
- SYK
- TP53
- KCNQ1
- KCMB2
- IFNG
- IDHC
- HSPB1
- GLI3
- GEMI
- GCR
- ESRRA
- CXCL8
- CREB1
- CP3A7
- CP3A4
- CP2CJ
- CP1A2
- CASP7
- CASP3
- TSHR
Drug classes
- Estrogen Receptor Agonists
- Contraceptive Agents
- Contraceptive Agents, Female
- Contraceptive Agents, Hormonal
- Contraceptives, Oral, Hormonal
- Estrogens
- Hormones
- Reproductive Control Agents
- Estrogen
- estrogenic hormone
ATC classes
- L02A · HORMONES AND RELATED AGENTS
- G03C · ESTROGENS
- HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Cross-references
Synonyms
- AFIRMELLE
- ALESSE
- ALTAVERA
- ALYACEN 1/35
- ALYACEN 7/7/7
- ANNOVERA
- ARANELLE
- ASHLYNA
- AUROVELA 1.5/30
- AUROVELA 1/20
- AUROVELA 24 FE
- AUROVELA FE 1.5/30
- ethinylestradiol
- ethinylestradiol betadex
- ethynyl estradiol
- 17-ethinylestradiol
- ethinyloestradiol
- Ethinylestradiol
- Etinilestradiol
- 17alpha-ethinylestradiol
- Enovid
- Enovid-e
- Ethinylestradiolum
- Ethynylestradiol
- Ginestrene
- Ovulen
- Ovulen-21
- Ovulen-28
- NSC-10973
- Estinyl
- Ethinyl estradiol component of alesse
- Ethinyl estradiol component of altavera
- Ethinyl estradiol component of annovera
- Ethinyl estradiol component of aranelle
- Ethinyl estradiol component of aviane
- Ethinyl estradiol component of balcoltra
- Ethinyl estradiol component of bekyree
- Ethinyl estradiol component of beyaz
Reported adverse events
- Cancer
- Breast cancer
- Dementia
- DVT
- TIA
- Cardiovascular disorder
- Nausea
- Headache
- Hirsutism
- Erythema nodosum
- Erythema multiforme
- Migraine
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