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PURVALANOL B
SynDRA canonical compound SYN0001434 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | MAPK3 |
|---|
| Mechanism of action | Tyrosine kinase inhibitor |
|---|
All known targets
- CDK2
- CDK4
- CDK5
- MAPK1
- MAPK3
- ADRB3
- CDK1
- SRPK2
Mechanisms of action (all sources)
- tyrosine kinase inhibitor
- CDK2 INHIBITOR
- CDK4/6 inhibitor
- CDK5 INHIBITOR
- CDK1 BINDER
- ADRB3 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- INSR
- NTRK2
- NTRK1
- ABL1
- TRIM24
- PRKCZ
- PRKCH
- PRKCG
- PRKCE
- PRKCD
- PRKCB
- PRKCA
- KDM4E
- HDAC6
- ALDH1A1
- GSK3B
- FGFR3
- CYP3A4
- CYP2D6
- CYP2C9
- CYP2C19
- CYP1A2
- CSNK1D
- BRPF1
- BRD4
- AURKA
- YES1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CCNA1
- CCNA2
- CCNB1
- CCNB2
- CCNB3
- CCNE1
- CCNE2
- CDK5R1
- KSYK
- PRKACA
- PRKACB
- PRKACG
- SYK
Cross-references
Synonyms
- L-751250
- PURVALANOL
- Purvalanol B(NG-95)
- (R)-2-chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzoic acid
- (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
- CHEMBL23254
- CHEBI:49840
- NG-95
- C20H25ClN6O3
- 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoic acid
- J-502183
- PVB
- purvalanol-b
- RefChem:870378
- DTXCID801747716
- MFCD04118312
- PurvalanolB
- Tocris-1581
- 1v0p
- Purvalanol B(NG-95)?
- SCHEMBL27951
- BDBM7478
- GTPL7806
- NG95
- orb1300012
- SCHEMBL29546074
- EX-A354
- HMS3268E21
- HMS3412L09
- HMS3676L09
- MIA84454
- AKOS024456681
- CS-1714
- EBC-520453
- NCGC00025220-01
- NCGC00025220-02
- NCGC00025220-03
- NCGC00025220-04
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