← SynDRA

SPERMINE

SynDRA canonical compound SYN0001423 — structure-anchored drug synonym record

All known targets

• CA14
• CA4
• CA6
• CA9
• CASR
• GRIN1
• GRIN2A
• KCNJ4
• TRPM4
• TRPM5
• NOS2
• ODC1

Mechanisms of action (all sources)

• CASR FULL AGONIST
• KCNJ4 ANTAGONIST
• TRPM4 ANTAGONIST
• TRPM5 MODULATOR
• GRIN2A INHIBITOR
• CA4 INHIBITOR
• GRIN1 INHIBITOR
• CA9 INHIBITOR
• CA6 INHIBITOR
• CA14 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• CASP2
• CA5A
• CA5B
• CA7
• RECQL
• HSD17B10
• MAOA
• MAOB
• MAPT
• OAZ1
• PAOX
• PMP22
• ALOX15
• SLC22A4
• GMNN
• SLC47A1
• SLC47A2
• TDP1
• TERT
• THPO
• UBE2N
• HDAC6
• EHMT2
• F13A1
• ERG
• AOC3
• APEX1
• APP
• ATAD5
• CA12
• CA2
• CASP3
• CXCR4
• CYP1A2
• CYP2C19
• CYP2C9
• CYP2D6
• CYP3A4
• DRD1
• ALOX15B

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP1A2
• CP2CJ
• RAD52

Cross-references

• PubChem CID: 1103
• ChEMBL: CHEMBL23194
• DrugBank: DB00127
• ChEBI: 15746
• KEGG: C00750
• RxNorm: 1483263
• PDB: SPM
• Wikipedia: Spermine
• TTD: D0LD9S

Synonyms

• 4,9-diazadodecamethylenediamine
• Actilip sp-91
• Gerotine
• Musculamine
• Neuridine
• NSC-268508
• neuridine
• musculamine
• gerontine
• Spermin
• 4,9-Diaza-1,12-dodecanediamine
• Diaminopropyltetramethylenediamine
• N,N'-Bis(3-aminopropyl)-1,4-butanediamine
• Spermine, puriss
• N,N'-Bis(3-aminopropyl)butane-1,4-diamine
• 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-
• 1,4-Bis(aminopropyl)butanediamine
• 4,9-Diazadodecamethylenediamine
• 4,9-Diazadodecane-1,12-diamine
• N1,N1'-(Butane-1,4-diyl)bis(propane-1,3-diamine)
• UNII-2FZ7Y3VOQX
• 1,4-Bis(aminopropyl) butanediamine
• Spermine Derivative
• 1,4-Diaminobutane, N,N'-bis
• Spermina
• 1,5,10,14-Tetraazatetradecane
• 1,4-Diaminobutane, N,N'-bis(3-aminopropyl)-
• 2FZ7Y3VOQX
• NSC 268508
• (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine
• CHEBI:15746
• diaminopropyl-tetramethylenediamine
• 1,4-Butanediamine, N1,N4-bis(3-aminopropyl)-
• (3-aminopropyl)((4-((3-aminopropyl)amino)butyl))amine
• RefChem:6255
• N,N'-Bis(3-aminopropyl)-1,4-diaminobutane
• MFCD00008215
• BRN 1750791