← SynDRA

SALIRASIB

SynDRA canonical compound SYN0001409 — structure-anchored drug synonym record

All known targets

• NRAS
• HRAS
• KRAS
• MTOR
• TRPA1

Mechanisms of action (all sources)

• HRAS INHIBITOR
• RAS inhibitor
• NRAS INHIBITOR
• KRAS INHIBITOR
• MTOR inhibitor
• NRAS ANTAGONIST
• MTOR MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• CDK2
• ALOX15B
• HSD17B10
• RECQL
• POLI
• POLH
• POLB
• NFKB1
• MPHOSPH8
• MAPT
• LMNA
• ICMT
• HIF1A
• BLM
• HDAC6
• GMNN
• EHMT2
• CYP3A4
• CYP2D6
• CYP2C9
• CYP2C19
• CYP1A2
• TSHR

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• BAP1
• CP1A2
• GEMI
• GPX4
• NTM1A
• NTMT1
• PE2R2

Drug classes

• Antineoplastic Agents
• Enzyme Inhibitors

Cross-references

• PubChem CID: 5469318
• ChEMBL: CHEMBL23293
• DrugBank: DB12681
• ChEBI: 177460
• KEGG: D08995
• TTD: D00KTV

Synonyms

• FTS
• Farnesylthiosalicylic acid
• S-Farnesylthiosalicylic acid
• UNII-MZH0OM550M
• MZH0OM550M
• CHEMBL23293
• AK186909
• Farnesyl Thiosalicylic Acid
• 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic Acid
• 2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylbenzoic acid
• 2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoic acid
• 2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic acid
• Benzoic acid, 2-(((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl)thio)-
• Farnesylthiosalicyclic acid
• FTS, Thyreos
• Ras antagonists, Thyreos
• S-trans
• Th-101
• Trans-farnesylthiosalicylicacid
• FTS (oral, cancer), Concordia
• Farnesylthiosalicyclic acid (oral, cancer), Concordia
• Ras-inhibitors (cancer), Concordia
• FTS (oral, cancer), Concordia/Ono
• KD032
• salirasibum
• RefChem:884413
• DTXCID70910920
• MFCD00467723
• trans,trans-Farnesyl thiosalicylic acid
• Salirasib [USAN]
• Farnesylthiosalicylate
• Salirasib [USAN:INN]
• S-trans,trans-farnesylthiosalicylic acid
• Salirasib?
• Salirasib; FTS
• SALIRASIB [INN]
• Salirasib (INN/USAN)
• Lopac-F-8175
• SALIRASIB [WHO-DD]