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MEFENAMIC ACID
SynDRA canonical compound SYN0001399 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | primary dysmenorrhea (PD) |
|---|
| Disease area | endocrinology |
|---|
All known targets
- PTGS2
- PTGS1
- KCNQ1
- TRPM3
- MPO
- TRPA1
- Nlrp3
- NAPRT
- AKR1B1
- AKR1B10
- KCNMA1
- DHFR
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- KCNMA1 MODULATOR
- KCNQ1 MODULATOR
- TRPM3 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ABCB11
- HRH1
- OPRD1
- NR3C1
- NR1H4
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- KCNK2
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- OPRK1
- OPRM1
- PDE3A
- SIGMAR1
- VDR
- TTR
- TDP1
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP1A2
- CP2C9
- CP3A7
- KCMB1
- KCMB2
- KCMB4
- LRC26
- NF2L2
- PRGR
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
- Nonsteroidal Anti-inflammatory Drug
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Cross-references
Synonyms
- PONSTEL
- mefenacid
- mephenamic acid
- mefenamate
- Acide mefenamique
- Acido mefenamico
- Gardan
- Mefenamate
- Mefenaminic acid
- Mephenamic acid
- Mephenaminic acid
- CI-473
- CN-35355
- INF-3355
- J2.344B
- M01AG01
- NSC-94437
- Contraflam
- Dysman-250
- Dysman-500
- Meflam 250
- Meflam 500
- Mendys
- Opustan 250
- Opustan 500
- Ponstan
- Ponstan fte
- Ponstel
- ApoMefenamic
- Bonabol
- Coslan
- Dysman
- Lysalgo
- Mefac
- Mefacit
- Mefedolo
- Mefenacid;Mefenamate
Reported adverse events
- Bleeding
- GI bleed
- Ulceration
- Agranulocytosis
- Stevens-Johnson syndrome
- Angioedema
- Asthma
- Hepatotoxicity
- Hypertension
- Alopecia
- Anaphylactoid reaction
- Anxiety
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