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DICLOFENAC
SynDRA canonical compound SYN0001394 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | migraine headache | osteoarthritis | rheumatoid arthritis |
|---|
| Disease area | neurology/psychiatry | rheumatology |
|---|
All known targets
- PTGS2
- PTGS1
- PPARG
- ASIC3
- TRPM3
- AKR1C3
- UGT1A7
- UGT1A6
- UGT1A10
- UGT1A1
- TTR
- TRPA1
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- ASIC3 MODULATOR
- PPARG ANTAGONIST
- SLC36A1 INHIBITOR
- TRPM3 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLC22A6
- ALB
- ESR1
- CYP2C9
- ADRA1A
- MPHOSPH8
- MAPK3
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- ABCB1
- NPY1R
- MAPK14
- NR1H2
- NR1H3
- NR1H4
- NR1I2
- NR1I3
- NR3C1
- NTSR1
- OPRD1
- NPY2R
- MAOA
- MAPK1
- OPRM1
- HDAC6
- HIF1A
- HMGCR
- HPGDS
- HRH1
- HRH2
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP2C9
- CP3A4
- ESRRA
- SC5A7
- TP53
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Enzyme Inhibitors
- Nonsteroidal Anti-inflammatory Drug
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- S01B · ANTIINFLAMMATORY AGENTS
- D11A · OTHER DERMATOLOGICAL PREPARATIONS
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Cross-references
Synonyms
- ARTHROTEC
- CAMBIA
- CATAFLAM
- Cambia
- Cataflam
- DICLOFENAC POTASSIUM
- DICLOFENAC SODIUM
- DICLOFENAC SODIUM AND MISOPROSTOL
- DYLOJECT
- FLECTOR
- Flector
- LICART
- diclofenac calcium
- diclofenac diethylamine
- diclofenac hydroxyethylpyrrolidine
- diclofenamic acid
- diclofenac sodium
- diclofenac potassium
- diclofenac epolamine
- Diclofenaco
- Arthrotec
- Diclofenac acid
- Diclofenac free acid
- LAS41007
- LAS-41007
- Voltaren ophthalmic
- Voltaren-xr
- Zorvolex capsules
- Dermatological agent (topical, actinic keratosis), Almirall
- Diclofenac (sodium matrix patch, pain)
- aceclofenac impurity a (ep impurity)
- Diclophenac
- Diclofenacum
- Allvoran
- CHEBI:47381
- Dicrofenac
- Voltaren-XR
- RefChem:6419
Reported adverse events
- GI bleed
- Bleeding
- Hepatotoxicity
- Ulceration
- Perforation
- Elderly
- Ulcer
- Abortion
- Uterine rupture
- P
- Teratogenicity
- Hypertension
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