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THIOTEPA
SynDRA canonical compound SYN0001342 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | Cytochrome P450 inhibitor |
|---|
| Indication | bladder cancer | breast cancer | ovarian cancer |
|---|
| Disease area | oncology |
|---|
All known targets
Mechanisms of action (all sources)
- Cytochrome P450 inhibitor
- CYP2B6 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH1
- SLC6A4
- HTR2A
- KCNH2
- DRD3
- HTR2C
- CHRM3
- CHRM2
- CHRM1
- SLC6A2
- HTR2B
- ADRA2C
- ADRA2B
- ADRA1A
- SLCO1B1
- OPRM1
- TDP1
- HTR3A
- TBXA2R
- KDR
- LMNA
- MAOA
- MC3R
- MLNR
- NR1I2
- NR3C1
- OPRD1
- PDE4D
- PDE3A
- SLC6A3
- PGR
- PLK1
- SMN1
- POLI
- PTGS2
- RGS4
- SLCO2B1
- SLC29A1
- SLCO1B3
- PPARG
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- GEMI
- SYK
- PRMT1
- PHGDH
- NTMT1
- NTM1A
- KSYK
- GLI3
- ESRRA
- ANDR
- ERAP1
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- TP53
Drug classes
- Alkylating Activity
- Alkylating Drug
- Alkylating Agents
- Antineoplastic Agents
- Antineoplastic Agents, Alkylating
- Immunologic Factors
- Immunosuppressive Agents
- Myeloablative Agonists
- Noxae
ATC classes
Cross-references
Synonyms
- TEPADINA
- TEPADINA AND SODIUM CHLORIDE
- TEPYLUTE
- THIOPLEX
- Tepadina
- Tepylute
- thio-tepa
- triethylenethiophosphortriamide
- oncotepa
- phosphorothioic acid triethylenetriamide
- tespamin
- tespamine
- thiophosphamide
- tepadina
- Tiotepa
- NSC-6396
- Thioplex
- Thiotepa riemser
- THIO-TEPA
- Triethylenethiophosphoramide
- Thiophosphamide
- Tiofosyl
- Tiofosfamid
- Thiofozil
- Tiofozil
- Tespamin
- Oncotepa
- Tespamine
- Girostan
- Thiotef
- Stepa
- TIO TEF
- Thio-Tep
- Oncotiotepa
- Tifosyl
- Oncothio-tepa
- TESPA
Reported adverse events
- Dysuria
- Dizziness
- Nausea
- Delirium
- Infection
- Renal failure
- Hypersensitivity
- Skin depigmentation
- Conjunctivitis
- Dermatitis
- Hepatomegaly
- Rash
Look up THIOTEPA in the interactive SynDRA portal →