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CYCLOBENZAPRINE
SynDRA canonical compound SYN0001333 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR2A |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | spasms |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HTR2A
- HTR2C
- ABCB1
- ADRA2C
- AOX1
- CACNA1B
- CHRM1
- CHRM2
- CHRM3
- HRH1
- HTR2B
- HTR6
Mechanisms of action (all sources)
- Serotonin receptor agonist
- Adrenergic receptor agonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- ADRA2C ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- KCNH2
- DRD1
- DRD2
- DRD3
- HTR1A
- ADRA1A
- HTR3A
- MLNR
- NR3C1
- NPY2R
- NPY1R
- MTOR
- MPHOSPH8
- HRH3
- MC4R
- IDH1
- OPRD1
- MC3R
- MAOA
- LMNA
- NTSR1
- ADORA1
- HDAC6
- SLCO1B3
- UGT1A4
- TSHR
- TRPV1
- TP53
- THPO
- TDP1
- TBXA2R
- SMPD1
- SLCO1B1
- OPRM1
- SLC6A3
- SLC29A1
- SAMHD1
- PTGS2
- PMP22
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- HNMT
- RARA
- PNMT
- NSD2
- NPR2
- NNMT
- MDR1
- KSYK
- JUN
- GNMT
- ACM4
- GLI3
- GAMT
- CP3A7
- CP3A4
- CP2D6
- CP1A2
- COMT
- ACM5
- SYK
Drug classes
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Central Nervous System Depressants
- Muscle Relaxants, Central
- Neuromuscular Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Tranquilizing Agents
- Muscle Relaxant
ATC classes
- M03B · MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Cross-references
Synonyms
- AMRIX
- Amrix
- CYCLOBENZAPRINE HYDROCHLORIDE
- FLEXERIL
- Fexmid
- TONMYA
- Tonmya
- proheptatrien
- proheptatriene
- cyclobenzaprine hydrochloride
- cyclobenzaprine HCl
- Ciclobenzaprina
- MK-130 (AS THE BASE)
- TNX-102
- Cyclobenz
- Cyclobenzaprinum
- Flexeril
- Lisseril
- Proeptatriene
- Proheptatrien
- Proheptatriene
- Yurelax
- Cyclobenzaprine [INN]
- Flexeril hydrochloride
- Proeptatriene [Italian]
- MK 130
- NCI78206
- Amrix (TN)
- Ciclobenzaprina [INN-Spanish]
- Cyclobenzaprine (INN)
- Cyclobenzaprinum [INN-Latin]
- Fexmid(TN)
- Flexeril (TN)
- MK-130 HCl
- Ro 4-1577
- Apo-Cyclobenzaprine (TN)
- N,N-Dimethyl-3-(dibenzo(a,d)cycloheptene-4-ylidene)propylamine
- N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine
Reported adverse events
- Chest pain
- Hypersensitivity
- Hypertension
- Purpura
- Seizure
- Syncope
- Tachycardia
- Vomiting
- Ageusia
- Dizziness
- Fatigue
- Headache
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