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METRONIDAZOLE
SynDRA canonical compound SYN0001327 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | DNA inhibitor |
|---|
| Indication | rosacea |
|---|
| Disease area | dermatology |
|---|
All known targets
- CYP2C9
- CYP3A4
- CNR1
- CYP2C8
- CYP2E1
- CYP3A5
- CYP3A7
Mechanisms of action (all sources)
- DNA inhibitor
- CNR1 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD2
- ACHE
- MBNL1
- OPRD1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- OPRM1
- MAPK14
- MAPK1
- MAOB
- MAOA
- LMNA
- LCK
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- OPRK1
- PDE3A
- HRH3
- SLC6A3
- VDR
- TSHR
- THRB
- TDP1
- TBXAS1
- TBXA2R
- TARDBP
- TACR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Nitroimidazole Antimicrobial
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antiparasitic Agents
- Antiprotozoal Agents
ATC classes
- D06B · CHEMOTHERAPEUTICS FOR TOPICAL USE
- P01A · AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
- G01A · ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- A01A · STOMATOLOGICAL PREPARATIONS
- J01X · OTHER ANTIBACTERIALS
- DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
- COMBINATIONS OF ANTIBACTERIALS
Cross-references
Synonyms
- BISMUTH SUBCITRATE POTASSIUM, METRONIDAZOLE AND TETRACYCLINE HYDROCHLORIDE
- BISMUTH SUBSALICYLATE, METRONIDAZOLE AND TETRACYCLINE HYDROCHLORIDE
- FLAGYL
- FLAGYL ER
- FLAGYL I.V.
- FLAGYL I.V. RTU IN PLASTIC CONTAINER
- Flagyl
- HELIDAC
- LIKMEZ
- Likmez
- METRO I.V.
- METRO I.V. IN PLASTIC CONTAINER
- anagiardil
- metronidazol
- metropol
- metrotab
- mexibol
- nidazole
- trichazol
- trichobrol
- metronidazole hydrochloride
- metronidazole phosphate
- metronidazole benzoate
- metronidazole HCl
- rozex
- Metronidazol
- Deflamon
- Gineflavir
- Orvagil
- BAY-5360
- BAYER-5360
- NSC-50364
- NSC-69587
- RP-8823
- Acea
- Anabact
- Drazifon
- Elyzol
Reported adverse events
- Hypersensitivity
- Dysuria
- Urticaria
- Toxic epidermal necrolysis
- Dermatitis bullous
- Headache
- Stevens-Johnson syndrome
- Nausea
- Dizziness
- Pruritus
- Constipation
- Abdominal discomfort
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