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MAPROTILINE
SynDRA canonical compound SYN0001318 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | SLC6A2 |
|---|
| Mechanism of action | Norepinephrine reputake inhibitor |
|---|
| Indication | depression | dysthymic disorder |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A2
- TRPM3
- DRD1
- SLC6A4
- SLC6A3
- Kcnj6
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HRH2
- HRH1
Mechanisms of action (all sources)
- Norepinephrine reputake inhibitor
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- TRPM3 MODULATOR
- norepinephrine reputake inhibitor, tricyclic antidepressant
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR2
- ADRB2
- PPARG
- ESR1
- KCNH2
- MAPK1
- NPC1
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- LCK
- NSD2
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- MTOR
- MAPK14
- LMNA
- PDE4D
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAOA
- MAPK3
- ABCB1
- PGR
- PDE5A
- SLC29A1
- TSHR
- TP53
- THPO
- TDP1
- TBXAS1
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- JUN
- KCMB2
- KSYK
- M4K2
- MAPT
- MCHR1
- MDM2
- MDM4
- MDR1
- NLRP1
- NPBW1
- NR1H4
- PA1B3
- RARA
- SYK
- TLR3
- KCMB1
- IL1B
- ACM1
- IFNG
- ACM4
- ACM5
- ANDR
- CASP3
- CASP7
- CP19A
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- ESRRA
- GLI3
- GNRHR
- IDHC
- TOR1A
Drug classes
- Adrenergic Agents
- Adrenergic Uptake Inhibitors
- Antidepressive Agents
- Antidepressive Agents, Second-Generation
- Central Nervous System Agents
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Tricyclic antidepressant
ATC classes
Cross-references
Synonyms
- LUDIOMIL
- MAPROTILINE HYDROCHLORIDE
- maprotiline hydrochloride
- maprotiline HCl
- Maprotilina
- BA-34,276 FREE BASE
- BA-34,276 [AS HYDROCHLORIDE]
- BA-34276 FREE BASE
- Deprilept
- Dibencycladine
- Maprotilin
- Maprotilinum
- Maprotylina
- Maprotylina [Polish]
- TBB066626
- BA-34276
- Deprilept (TN)
- Ludiomil (TN)
- Maprotilina [INN-Spanish]
- Maprotiline (USAN)
- Maprotilinum [INN-Latin]
- Psymion (TN)
- Ba-34,276
- Maprotiline [USAN:BAN:INN]
- N-Methyl-9,10-ethanoanthracene-9(10H)-propanamine
- N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine
- 9,10-Ethanoanthracene-9(10H)-propanamine, N-methyl-
- 276-Ba
- CHEBI:6690
- 2U1W68TROF
- 9,10-Ethanoanthracene-9(10H)-propylamine, N-methyl-
- NCGC00015708-04
- MAPROTILINE [USAN]
- CAS-10262-69-8
- EINECS 233-599-4
- CAS-10347-81-6
- UNII-2U1W68TROF
- BRN 2385493
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