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DIPHENHYDRAMINE
SynDRA canonical compound SYN0001312 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH1 |
|---|
| Mechanism of action | Histamine receptor antagonist |
|---|
| Indication | headache |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HRH1
- CHRM1
- HTR2C
- SLC6A3
- SLC6A2
- SLC22A2
- SCN3A
- SCN2A
- SCN1A
- KCNH2
- HTR2B
- CHRM2
Mechanisms of action (all sources)
- Histamine receptor antagonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
- HNMT INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR5A
- ADRA2B
- NPY1R
- NPY2R
- DRD3
- HRH2
- ESR1
- ADRA2A
- ADRA1A
- HTR6
- PDE4D
- PDE4A
- PDE3A
- MLNR
- OPRK1
- OPRD1
- NTSR1
- NR3C1
- PDE5A
- MMP9
- MMP1
- OPRM1
- MC5R
- MDH1
- LMNA
- HTR7
- HTT
- KAT2A
- KDM4E
- KDR
- LCK
- MAOA
- PGR
- MAPK1
- MAPK14
- MAPK3
- MBNL1
- MC3R
- MC4R
- PDE6A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- ACM4
- ACM5
- CP1A2
- CP2D6
- CP3A4
- GLI3
- IF4H
- JUN
- MK01
- NR1I2
Drug classes
- Histamine H1 Receptor Antagonists
- Histamine-1 Receptor Antagonist
- Anesthetics
- Anesthetics, Local
- Anti-Allergic Agents
- Antiemetics
- Central Nervous System Agents
- Central Nervous System Depressants
- Gastrointestinal Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
ATC classes
- D04A · ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
Cross-references
Synonyms
- ADVIL PM
- ALEVE PM
- ANTITUSSIVE
- Aleve PM
- BELDIN
- BELIX
- BENADRYL
- BENADRYL PRESERVATIVE FREE
- BENYLIN
- Banophen
- Benadryl
- Caladryl
- benadryl
- diphenhydramine salicylate
- diphenhydramine laurylsulfate
- benzhydramine
- probedryl
- diphenhydramine hydrochloride
- diphenhydramine citrate
- diphenhydramine HCl
- Difenhidramina
- Diphenhdyra
- Restamin
- Benzhydramine
- Probedryl
- Alledryl
- Antistominum
- Dihidral
- 2-(Benzhydryloxy)-N,N-dimethylethanamine
- Benzhydraminum
- Benzhydroamina
- Diphantine
- Difenhydramin
- Ibiodral
- Difedryl
- Dibondrin
- Mephadryl
- Desentol
Reported adverse events
- Hypotension
- Sedation
- Urticaria
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