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ESTRADIOL
SynDRA canonical compound SYN0001311 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR1I2 |
|---|
| Mechanism of action | Estrogen receptor agonist |
|---|
| Indication | contraceptive |
|---|
| Disease area | endocrinology |
|---|
All known targets
- ESR1
- ESR2
- GPER1
- NR1I2
- KCNMA1
- ALOX15
- SRD5A3
- SRD5A2
- SRD5A1
- SNCA
- SLC6A4
- SLC6A3
Mechanisms of action (all sources)
- ESR1 AGONIST
- ESR1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HSD17B1
- SLC22A1
- SULT1A1
- AKR1B10
- SLC22A3
- SULT1E1
- PDE4D
- PDE4A
- PPARG
- PPARD
- MMP1
- MMP9
- NPY1R
- NPY2R
- NR1H4
- NTSR1
- OPRD1
- PMP22
- MLNR
- OPRM1
- PDE5A
- P4HB
- PDE3A
- OPRK1
- MC5R
- PRKCA
- IDH1
- HSD17B7
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- HTR5A
- HTR6
- HTR7
- KCNH2
- MC4R
- KDR
- LCK
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- KCMA1
- SYK
- STK33
- SMAD2
- RARA
- PRGR
- NSD2
- KSYK
- IFNG
- CASP3
- GLI3
- GCR
- CP3A7
- CP2D6
- CP2CJ
- CP19A
- CASP7
- TP53
Drug classes
- Estrogen Receptor Agonists
- Estrogens
- Hormones
- Estrogen
- Contraceptive Agents
- Contraceptive Agents, Female
- Contraceptive Agents, Hormonal
- Reproductive Control Agents
- contraceptive agent
ATC classes
- L02A · HORMONES AND RELATED AGENTS
- G03C · ESTROGENS
- HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
- HYPOTHALAMIC HORMONES
Cross-references
Synonyms
- ACTIVELLA
- ALORA
- AMABELZ
- AMNESTROGEN
- ANGELIQ
- Alora
- BIJUVA
- CLIMARA
- CLIMARA PRO
- COMBIPATCH
- Climara
- Climara Pro
- 17Beta-Estradiol
- 17Beta-Oestradiol
- Beta-Estradiol
- estradiol hemihydrate
- polyestradiol phosphate
- estradurin
- polyestrol phosphate
- Estradiol hemihydrate
- 17 .beta.-estradiol
- 17-.beta.-oestradiol
- 17-beta-oestradiol
- 17.beta.-estradiol
- 17beta-estradiol
- Aerodiol
- Estradiol 17-beta
- Estradiol anhydrous
- Estradiol valerate metabolite e2
- NSC-20293
- NSC-9895
- S 21400
- S21400
- S21400 (INTRANASAL)
- WC-3011
- WC3011
- Adgyn estro
- Aquagen
Reported adverse events
- Dementia
- Endometrial cancer
- Cardiovascular disorder
- DVT
- Cancer
- TIA
- UTI
- Breast cancer
- Headache
- Hirsutism
- Urticaria
- Erythema
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