CLONIDINE

SynDRA canonical compound SYN0001306 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	ADRA2C
Mechanism of action	Adrenergic receptor agonist
Indication	attention-deficit/hyperactivity disorder (ADHD) \| hypertension
Disease area	cardiology \| neurology/psychiatry

All known targets

ADRA2B
ADRA2C
ADRA2A
ADRA1D
ADRA1A
SLC22A1
ADRA1B
Hcn1
SLC47A1
SLC22A2
Nisch
NISCH

Mechanisms of action (all sources)

Adrenergic receptor agonist
ADRA2A AGONIST
Adrenergic receptor alpha-2 agonist
ADRA2C AGONIST
ADRA2B AGONIST
TADA2A AGONIST
ADRA1D AGONIST
ADRA2A PARTIAL AGONIST
ADRA2B PARTIAL AGONIST
SLC22A1 INHIBITOR
AOC3 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

CP2C9
CP2CJ
CP2D6
MDR1
S22A1

Drug classes

Adrenergic alpha2-Agonists
Central alpha-2 Adrenergic Agonist
Adrenergic Agents
Adrenergic Agonists
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-Agonists
Analgesics
Antihypertensive Agents
Cardiovascular Agents
Central Nervous System Agents
Neurotransmitter Agents
Peripheral Nervous System Agents

ATC classes

C02A · ANTIADRENERGIC AGENTS, CENTRALLY ACTING
N02C · ANTIMIGRAINE PREPARATIONS
S01E · ANTIGLAUCOMA PREPARATIONS AND MIOTICS
ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION

Cross-references

PubChem CID: 2803
ChEMBL: CHEMBL134
DrugBank: DB00575
ChEBI: CHEBI:46631
KEGG: D00281
RxNorm: 2599
PDB: CLU
Wikipedia: Clonidine
TTD: D03SKR
LINCS BRD: BRD-K98530306

Synonyms

Reported adverse events

Thrombocytopenia
Alopecia
Fatigue
Accommodation disorder
Abdominal pain
Agitation
Bradycardia
Raynaud's phenomenon
Rash
Nausea
Nervousness
Syncope

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