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ATOMOXETINE
SynDRA canonical compound SYN0001288 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Norepinephrine transporter inhibitor |
|---|
| Indication | attention-deficit/hyperactivity disorder (ADHD) |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A2
- SLC6A4
- SLC6A3
- CYP2D6
- GRIN1
- Slc6a3
- Slc6a2
- NET
- KLF10
- KCNJ6
- KCNJ5
- KCNJ3
Mechanisms of action (all sources)
- Norepinephrine transporter inhibitor
- SLC6A2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2A
- DRD3
- OPRK1
- ABCC2
- MAPK1
- MAOA
- IDH1
- HTR3A
- HTR2C
- HTR2B
- HTR1A
- MLNR
- HRH3
- HRH2
- HRH1
- HDAC6
- GSK3B
- GMNN
- MC3R
- NPY1R
- GHSR
- NR1I2
- TRIM24
- TDP1
- TBXA2R
- SLCO2B1
- SLCO1B3
- SLCO1B1
- SAMHD1
- PTGS2
- PGR
- PDE4D
- PDE3A
- OPRM1
- OPRL1
- OPRD1
- NR3C1
- GLP1R
- FGFR2
- ABL1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- ANDR
- CP1A2
- CP2D6
- ESR2
- ESRRA
- GLI3
- JUN
- KCMB2
- SC6A3
- SC6A4
Drug classes
- Norepinephrine Uptake Inhibitors
- Adrenergic Agents
- Adrenergic Uptake Inhibitors
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Norepinephrine Reuptake Inhibitor
ATC classes
- N06B · PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Cross-references
Synonyms
- ATOMOXETINE HYDROCHLORIDE
- ATONCY
- Atoncy
- STRATTERA
- Strattera
- LY139603
- strattera
- tomoxetine
- (-)-Tomoxetine
- atomoxetine hydrochloride
- tomoxetine hydrochloride
- atomoxetine HCl
- tomoxetine HCl
- Atomoxetina
- Atomoxetine component of ad-109
- Atomoxetine component of ad-313
- Atomoxetine component of ad109
- Atomoxetine component of ad313
- Tomoxetina
- Tomoxetine
- Tomoxetinum
- Tomoxetina [Spanish]
- Tomoxetine [INN]
- Tomoxetinum [Latin]
- Atomoxetine (INN)
- Attentin (TN)
- Strattera (TN)
- Tomoxetin (TN)
- AD-313 COMPONENT ATOMOXETINE
- AD109 COMPONENT ATOMOXETINE
- ASW034S0B8
- AD313 COMPONENT ATOMOXETINE
- AD-109 COMPONENT ATOMOXETINE
- CHEBI:127342
- Tomoxetinum (Latin)
- atomoxetinum
- RefChem:56721
- DTXCID7024297
Reported adverse events
- Abdominal pain
- Dizziness
- Dry mouth
- Dysuria
- Fatigue
- Headache
- Insomnia
- Nausea
- Seizure
- Palpitations
- Weight decreased
- Constipation
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