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AZELASTINE
SynDRA canonical compound SYN0001285 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH1 |
|---|
| Mechanism of action | Histamine receptor antagonist |
|---|
| Indication | conjunctivitis |
|---|
| Disease area | ophthalmology |
|---|
All known targets
- HRH1
- ABCB1
- ADRA1A
- ADRA1B
- Adra1a
- CHRM1
- CYP2C19
- HRH3
- HTR2B
- HTR2C
- KCNH2
Mechanisms of action (all sources)
- Histamine receptor antagonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLC6A2
- DRD2
- DRD3
- CYP2D6
- DRD4
- NR1I2
- SIGMAR1
- CHRM4
- CHRM3
- CHRM2
- SLC6A3
- SLC6A4
- HTR1B
- HTR1D
- HTR1E
- HTR2A
- ADRB3
- HTR3A
- HTR5A
- ADRA2C
- ADRA2B
- ADRA2A
- ADRA1D
- HTR6
- TMEM97
- HTR7
- DRD1
- OGG1
- NR3C1
- ABCB11
- NEIL2
- NEIL1
- MPG
- MLNR
- OPRM1
- OPRD1
- PTGS2
- PDE3A
- PDE4D
- TSPO
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- KCMA1
- SYK
- SC5A7
- MDR1
- KSYK
- KCMB4
- KCMB2
- KCMB1
- JUN
- ACES
- IDHC
- GPR151
- GLI3
- CP3A7
- CP3A4
- CP2D6
- ACM1
- TSHR
Drug classes
- Histamine H1 Receptor Antagonists
- Histamine-1 Receptor Antagonist
- Anti-Allergic Agents
- Anti-Asthmatic Agents
- Bronchodilator Agents
- Enzyme Inhibitors
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Histamine H1 Antagonists, Non-Sedating
- Lipoxygenase Inhibitors
- Neurotransmitter Agents
ATC classes
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
- S01G · DECONGESTANTS AND ANTIALLERGICS
Cross-references
Synonyms
- ASTELIN
- ASTEPRO
- ASTEPRO ALLERGY
- AZELASTINE HYDROCHLORIDE
- AZELASTINE HYDROCHLORIDE ALLERGY
- AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATE
- AZELASTINE HYDROCHLORIDE CHILDREN'S ALLERGY
- Astepro
- CHILDREN'S ASTEPRO ALLERGY
- DYMISTA
- Dymista
- OPTIVAR
- azelastine hydrochloride
- azelastine HCl
- Azelastina
- NSC-758971
- Azelastinum
- Optivar
- Astelin (TN)
- Astepro (TN)
- Azelastina [INN-Spanish]
- Azelastine (INN)
- Azelastine [INN:BAN]
- Azelastinum [INN-Latin]
- Optivar (TN)
- 4-(p-chlorobenzyl)-2-(N-methylperhydroazepinyl-(4))-1-(2H)-phthalazinone
- NSC 758971
- ZQI909440X
- CHEBI:2950
- a-5610
- Vividrin akut Azelastin
- RefChem:54397
- DTXCID502638
- R01AC03
- R06AX19
- S01GX07
- Optilast
- AZELASTINE [INN]
Reported adverse events
- Epistaxis
- Somnolence
- Headache
- Fatigue
- Nausea
- Sneezing
- Dizziness
- Pharyngitis
- Rhinitis
- Sinusitis
- Weight
- Dysgeusia
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