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VORICONAZOLE
SynDRA canonical compound SYN0001284 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS1 |
|---|
| Mechanism of action | Cytochrome P450 inhibitor |
|---|
| Indication | aspergillosis | esophageal candidiasis | skin infections |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP2C19
- CYP2C9
- CYP3A4
- CYP3A5
- PTGS1
- CYP11A1
- CYP46A1
- CYP51
- CYP51A1
- Candi ERG11
- ERG11
- cyp51
Mechanisms of action (all sources)
- Cytochrome P450 inhibitor
- Candi ERG11 MODULATOR
- ERG11 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYP2B6
- ACHE
- HRH3
- HTR2B
- KCNH2
- KDR
- MAOA
- MAPK1
- OPRM1
- PDE3A
- PDE4A
- PGR
- RELA
- SAMHD1
- SLC6A2
- SLC6A3
- SLC6A4
- HTR1A
- HDAC6
- ADORA3
- F2
- ESR1
- DRD3
- DRD1
- CYP2D6
- CYP2C8
- CYP2A6
- CYP27A1
- CYP1A2
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- CYP3A43
- CYP3A7
- LRC26
Drug classes
- Azole Antifungal
- Cytochrome P450 2C19 Inhibitors
- Cytochrome P450 3A4 Inhibitors
- Cytochrome P450 2C9 Inhibitors
- 14-alpha Demethylase Inhibitors
- Anti-Infective Agents
- Antifungal Agents
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Hormone Antagonists
- Metabolic Side Effects of Drugs and Substances
ATC classes
- J02A · ANTIMYCOTICS FOR SYSTEMIC USE
Cross-references
Synonyms
- VFEND
- Vfend
- voriconazol
- vfend
- UK109496
- UK 109496
- Voriconazol
- NSC-759888
- UK-109,496
- UK-109496
- Voriconazole accord
- Voriconazole hikma (previously voriconazole hospira)
- VCZ
- Pfizer brand of voriconazole
- Voriconazole in combination with MGCD290
- DRG-0301
- VFEND (TN)
- Vfend, Voriconazole
- Voriconazole [USAN:INN:BAN]
- Voriconazole (JAN/USAN/INN)
- VRC
- voriconazole (ep monograph)
- voriconazole (usp monograph)
- JFU09I87TR
- voriconazole (usp-rs)
- NSC 759888
- Voriconazolum
- CHEBI:10023
- DTXCID3026485
- RefChem:56222
- UK109,496
- J02AC03
- (+/-)-Voriconazole
- Voriconazole Vfend
- MFCD00905717
- Voriconzole
- C16H14F3N5O
Reported adverse events
- Stevens-Johnson syndrome
- Rash
- Arrhythmia
- Chills
- Chromatopsia
- Fluorosis
- Hallucination
- Headache
- Nausea
- Photophobia
- Tachycardia
- Vomiting
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