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AMIODARONE
SynDRA canonical compound SYN0001275 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | KCNH2 |
|---|
| Mechanism of action | Potassium channel blocker |
|---|
| Indication | ventricular arrhythmias |
|---|
| Disease area | cardiology |
|---|
All known targets
- KCNH2
- KCNA7
- CHRM5
- CHRM3
- CACNA1H
- SCN5A
- ADRB1
- KDM5A
- Htr1b
- PHF2
- MC3R
- MC4R
Mechanisms of action (all sources)
- Potassium channel blocker
- KCNH2 BLOCKER
- KCNA7 MODULATOR
- CHRM5 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- CACNA1C
- HRH1
- GHSR
- ESR2
- MTOR
- NR3C1
- HRH3
- ADRA1A
- TP53
- NPY2R
- NPY1R
- NPSR1
- NFKB1
- NEIL2
- MUTYH
- TTR
- MPHOSPH8
- MPG
- MMP9
- MMP1
- MLNR
- MBD4
- TRIM24
- MAPK3
- UBE2N
- MAPK14
- MAPK1
- MAOA
- UNG
- LMNA
- LCK
- KDM4A
- IDO1
- IDH1
- HTT
- USP1
- MAPT
- OGG1
- PDE3A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- KSYK
- MDR1
- MLLT3
- NR1I2
- PRGR
- RAD52
- RARA
- SCN10A
- SCN11A
- SCN1A
- SCN2A
- SCN3A
- SCN4A
- SCN7A
- SCN8A
- SCN9A
- M4K2
- IFNG
- ANDR
- GLI3
- APAF
- ASM
- CACNA1D
- CACNA1F
- CACNA1S
- CASP3
- CASP7
- CP19A
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A7
- ESRRA
- GEMI
- SYK
Drug classes
- Antiarrhythmic
- Anti-Arrhythmia Agents
- Cardiovascular Agents
- Cytochrome P-450 CYP1A2 Inhibitors
- Cytochrome P-450 CYP2C9 Inhibitors
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Membrane Transport Modulators
- Metabolic Side Effects of Drugs and Substances
- Potassium Channel Blockers
ATC classes
- C01B · ANTIARRHYTHMICS, CLASS I AND III
Cross-references
Synonyms
- AMIODARONE HYDROCHLORIDE
- CORDARONE
- NEXTERONE
- Nexterone
- PACERONE
- Pacerone
- amidorone
- sedacoron
- amiodarone hydrochloride
- amiodarone HCl
- Amiodarona
- Amidorone
- Aminodarone
- Amiobeta
- Amiodarex
- Amiodarons
- Amiodaronum
- Amiohexal
- Amjodaronum
- Ancar
- Aratac;Arycor
- Braxan
- Corbionax
- Cordarex
- Cordarone
- Kordaron
- Labaz
- Ortacrone
- Rytmarone
- Sedacoron
- Sedacorone
- Tachydaron
- ASTA Medica Brand of Amiodarone Hydrochloride
- Alphapharm Brand of Amiodarone Hydrochloride
- Amiodarone Base
- Armstrong Brand of Amiodarone Hydrochloride
- Berenguer Infale Brand of Amiodarone Hydrochloride
- Betapharm Brand of Amiodarone Hydrochloride
Reported adverse events
- Pulmonary toxicity
- Liver injury
- Bradycardia
- Hypothyroidism
- Nausea
- Constipation
- Flushing
- Malaise
- Solar dermatitis
- Stevens-Johnson syndrome
- Arrhythmia
- Abdominal pain
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