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SUMATRIPTAN
SynDRA canonical compound SYN0001271 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR1F |
|---|
| Mechanism of action | Serotonin receptor agonist |
|---|
| Indication | migraine headache |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HTR1D
- HTR1B
- HTR1A
- HTR1F
- HTR5A
- HTR1E
- HTR6
- HTR7
- Htr1b
- Htr7
- Htr6
- Htr5a
Mechanisms of action (all sources)
- Serotonin receptor agonist
- HTR1B AGONIST
- Serotonin 1b (5-HT1b) receptor agonist
- HTR1D AGONIST
- Serotonin 1d (5-HT1d) receptor agonist
- HTR1A FULL AGONIST
- HTR1B PARTIAL AGONIST
- HTR1D FULL AGONIST
- HTR1E FULL AGONIST
- HTR1F FULL AGONIST
- HTR5A FULL AGONIST
- HTR6 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- MAPK1
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAOA
- OPRK1
- LCK
- KCNH2
- HTR2B
- HRH2
- HRH1
- HMGCR
- HDAC6
- GMNN
- GIPR
- GHSR
- GCGR
- GABBR1
- OPRD1
- OPRM1
- FLT1
- SLC22A1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT1E
- 5HT1F
- 5HT2A
- 5HT5A
- 5HT6R
- 5HT7R
- CP2D6
Drug classes
- Serotonin 1b Receptor Agonists
- Serotonin 1d Receptor Agonists
- Serotonin-1b and Serotonin-1d Receptor Agonist
- Cardiovascular Agents
- Neurotransmitter Agents
- Serotonin 5-HT1 Receptor Agonists
- Serotonin Agents
- Serotonin Receptor Agonists
- Vasoconstrictor Agents
ATC classes
- N02C · ANTIMIGRAINE PREPARATIONS
Cross-references
Synonyms
- ALSUMA
- IMITREX
- IMITREX STATDOSE
- Imitrex
- ONZETRA XSAIL
- SUMATRIPTAN AND NAPROXEN SODIUM
- SUMATRIPTAN SUCCINATE
- SUMAVEL DOSEPRO
- TOSYMRA
- TREXIMET
- Tosymra
- GR43175
- GR 43175
- sumatriptan succinate
- Dfn-11
- Dfn-11 (sumatriptan injection)
- N02CC01
- Sumatran
- Sumatriptanum
- Sumax
- GR-43175
- GR 43175X
- NP101
- Imigran (TN)
- Imitrex (TN)
- KS-1116
- Sumatriptanum [INN-Latin]
- Sumatriptan (JAN/USP/INN)
- 3-[2-(Dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide
- Imigran
- sumatriptan (usp-rs)
- sumatriptan (usp monograph)
- DFN-11 (SUMATRIPTAN INJECTION)
- DFN-11
- 8R78F6L9VO
- Imigran Recovery
- DTXCID303628
Reported adverse events
- Bleeding
- Elderly
- GI bleed
- Perforation
- Ulceration
- Seizure
- Malaise
- Arrhythmia
- Headache
- Serotonin syndrome
- Medication overuse headache
- Hypotension
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