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AMITRIPTYLINE
SynDRA canonical compound SYN0001267 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Norepinephrine reuptake inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A4
- SLC6A2
- CHRM1
- HTR6
- CHRM5
- CHRM4
- CHRM3
- CHRM2
- HRH1
- ADRA1A
- ADRA1D
- NTRK1
Mechanisms of action (all sources)
- Norepinephrine inhibitor
- Serotonin reuptake inhibitor
- Serotonin receptor antagonist
- Norepinephrine reuptake inhibitor
- SLC6A4 INHIBITOR
- Serotonin transporter inhibitor
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- HTR6 ANTAGONIST
- ADRA1A ANTAGONIST
- HRH1 ANTAGONIST
- LPAR1 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PARP1
- ESR2
- ESR1
- NR1I2
- HTR3A
- AGTR1
- DRD4
- SCN3A
- ABCB1
- NR3C1
- NTSR1
- PDE4A
- PDE3A
- NPY2R
- PDE4D
- PDE5A
- PGR
- PLAUR
- NR1H4
- NPY1R
- PPARD
- NFKB1
- NFE2L2
- MTOR
- MPHOSPH8
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MBNL1
- MAPT
- MAPK3
- MAPK14
- PMP22
- PPP3CA
- PPARG
- UGT1A1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- GLI3
- TLR3
- SCN1A
- RARA
- PRGR
- PNMT
- NNMT
- MDR1
- KCMB4
- KCMB2
- KCMA1
- JUN
- IFNG
- HNMT
- GNMT
- GAMT
- 5HT6R
- ESRRA
- CP3A7
- CP2D6
- CP2CJ
- CP1A2
- COMT
- CASP7
- CASP3
- ANDR
- ACM5
- ACM4
- ACM3
- ACM2
- ACM1
- TSHR
Drug classes
- Adrenergic Agents
- Adrenergic Uptake Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Peripheral Nervous System Agents
- Psychotropic Drugs
ATC classes
- N06A · ANTIDEPRESSANTS
- PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
Cross-references
Synonyms
- AMITID
- AMITRIL
- AMITRIPTYLINE HYDROCHLORIDE
- CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE
- ELAVIL
- ENDEP
- ETRAFON 2-10
- ETRAFON 2-25
- ETRAFON-A
- ETRAFON-FORTE
- Elavil
- LIMBITROL
- amitriprolidine
- amitriptylin
- damitriptyline
- amitriptyline hydrochloride
- amitryptiline
- amitryptiline hydrochloride
- amitriptyline HCl
- amitryptiline HCl
- Amitriptilina
- Damitriptyline
- Flavyl
- Laroxyl
- Proheptadiene
- Seroten
- Triptanol
- Adepress
- Adepril
- Amitril
- Amitriprolidine
- Amitriptylin
- Amitriptylinum
- Amitryptiline
- Amitryptyline
- Amytriptiline
- Amytriptylin
- Damilan
Reported adverse events
- Alopecia
- Myocardial infarction
- Testicular swelling
- Coma
- Hepatic failure
- Lupus-like syndrome
- Akathisia
- Nausea
- Hypotension
- Anaphylactoid reaction
- Dyskinesia
- Dystonia
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