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PENTOXIFYLLINE
SynDRA canonical compound SYN0001266 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PDE5A |
|---|
| Mechanism of action | Phosphodiesterase inhibitor |
|---|
| Indication | claudication |
|---|
| Disease area | cardiology |
|---|
All known targets
- PDE4B
- ADORA2B
- PDE5A
- ADORA2A
- PDE4A
- PDE6D
- PDE6A
- PDE6B
- PDE6C
- PDE7A
- PDE6G
- PDE4C
Mechanisms of action (all sources)
- Phosphodiesterase inhibitor
- ADORA2B ANTAGONIST
- Adenosine A2 receptor antagonist
- ADORA2A ANTAGONIST
- PDE5A INHIBITOR
- 3',5'-cyclic phosphodiesterase inhibitor
- PDE4A INHIBITOR
- PDE3A INHIBITOR
- PDE6H INHIBITOR
- PDE6G INHIBITOR
- PDE2A INHIBITOR
- PDE7A INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA3
- MAPK14
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- NFKB1
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK1
- HRH1
- MAOA
- LMNA
- LCK
- KCNH2
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- OPRD1
- OPRK1
- OPRM1
- PGR
- USP2
- TSHR
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMN1
- SLCO1B3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antioxidants
- Cardiovascular Agents
- Enzyme Inhibitors
- Free Radical Scavengers
- Hematologic Agents
- Phosphodiesterase Inhibitors
- Platelet Aggregation Inhibitors
- Protective Agents
- Radiation-Protective Agents
- Vasodilator Agents
- Blood Viscosity Reducer
ATC classes
- C04A · PERIPHERAL VASODILATORS
Cross-references
Synonyms
- PENTOXIL
- TRENTAL
- azupentat
- dimethyloxohexylxanthine
- oxpentifylline
- pentoxifyllin
- Oxpentifylline
- Pentoxifilina
- Oxypentifylline
- Pentoxiphyllin
- BL-191
- C04AD03
- NSC-637086
- NSC-758481
- Neotren mr
- Pentoxil
- Trental
- Trental 100
- Trental 400
- Agapurin
- Azupentat
- Dimethyloxohexylxanthine
- Durapental
- Hemovas
- Ikomio
- PENTOXYPHYLINE;PNX
- Pentoxifyllin
- Pentoxifyllinum
- Pentoxiphylline
- Pentoxiphyllium
- Pentoxyfylline
- Pentoxyphyllin
- Pentoxyphylline
- Ralofect
- Rentylin
- Torental
- Trental;Vasofirin
Reported adverse events
- Agitation
- Arrhythmia
- Dizziness
- Dyspepsia
- Flushing
- Headache
- Insomnia
- Nausea
- Nervousness
- Tremor
- Vomiting
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