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TRAZODONE
SynDRA canonical compound SYN0001233 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Adrenergic receptor antagonist |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A4
- HTR2C
- HTR2A
- HTR2B
- HTR1A
- HRH1
- ADRA1A
- ADRA2A
- HTR7
- SLC6A3
- SLC6A2
- SIGMAR1
Mechanisms of action (all sources)
- Serotonin reuptake inhibitor
- Serotonin receptor antagonist
- Adrenergic receptor antagonist
- SLC6A4 INHIBITOR
- Serotonin transporter inhibitor
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- HTR2B ANTAGONIST
- SLC6A4 MODULATOR
- HTR1A MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TACR1
- ADRB2
- ABCB1
- KDM4E
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- HTR6
- KAT2A
- NPY1R
- HTR3A
- HSD17B10
- HRH3
- HPGD
- HMGCR
- HIF1A
- HDAC6
- HCAR2
- GMNN
- GIPR
- MMP9
- NR3C1
- NPY2R
- PTGS2
- USP1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- SMPD1
- SLCO1B3
- SLCO1B1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2B
- ALR
- CP2D6
- CP3A7
- ESRRA
- GLI3
- HTR1E
- MDR1
- NF2L2
- NR1I2
- NTM1A
- PRGR
Drug classes
- Anti-Anxiety Agents
- Antidepressive Agents
- Antidepressive Agents, Second-Generation
- Central Nervous System Agents
- Central Nervous System Depressants
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Selective Serotonin Reuptake Inhibitors
- Serotonin Agents
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- DESYREL
- OLEPTRO
- RALDESY
- Raldesy
- TRAZODONE HYDROCHLORIDE
- TRIALODINE
- trazodon
- trazodone hydrochloride
- trazodone HCl
- Trazodona
- Trittico
- J10.767K
- Beneficat
- Desirel
- Sideril
- Tradozone
- Trazalon
- Trazodil
- Trazodon
- Trazodonum
- Trazolan
- Trazonil
- Trialodine
- Desyrel Dividose
- Trazodona [Spanish]
- Trazodone Hcl
- Trazodonum [Latin]
- Beneficat (TN)
- Deprax (TN)
- Desirel (TN)
- Desyrel (TN)
- Desyrel(trazodone hcl salt)
- Molipaxin (TN)
- Thombran (TN)
- Trazodona [INN-Spanish]
- Trazodone (Desyrel)
- Trazodone (INN)
- Trazodone [INN:BAN]
Reported adverse events
- Nausea
- Constipation
- Fatigue
- Headache
- Hypertension
- Hypotension
- Malaise
- Syncope
- Vomiting
- Disorientation
- Nervousness
- Tremor
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