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GELDANAMYCIN
SynDRA canonical compound SYN0001219 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | HSP90AA1 |
|---|
| Mechanism of action | HSP inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- HSP inhibitor
- HSP90AA1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KDM6B
- KDM4C
- KDM4B
- TRAP1
- HSP90AB1
- KDM5A
- MAPK11
- MAPK3
- MAPK6
- NEK2
- PLK1
- NEK6
- OXSR1
- PAK4
- PAK5
- PAK6
- PBK
- PDPK1
- PIM1
- PIM2
- PIM3
- PLK4
- MAP2K6
- PRKAA2
- VRK2
- VRK1
- VDR
- TNIK
- STK4
- STK38
- STK3
- STK26
- STK25
- STK17A
- STK16
- STK10
- SLK
- RPS6KA3
- RIPK1
- RIOK2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antibiotics, Antineoplastic
- Antiviral Agents
- Cysteine Proteinase Inhibitors
- Enzyme Inhibitors
Cross-references
Synonyms
- NSC-122750
- GDM
- GMY
- Geldanamicin
- Geldanomycin
- Geldaramycin
- Antibiotic U 29135
- BODIPY-labeled Geldanamycin
- Geldanamycin (9CI)
- Geldanamycin, Streptomyces hygroscopicus
- U-29135
- Antibiotic (U-29,135)
- [(8E,12E,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(8E,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(8Z,12Z,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(3R,5R,6S,7R,10R,11R)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(3R,5S,6R,7S,10R,11R)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(3R,5S,6R,7S,10S,11S)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(3S,5S,6R,7S,8E,10R,11S,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate
- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(3R,5S,6R,7S,8E,10R,11R,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- [(3S,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
- (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
- (6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl) carbamate
- [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione
- 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
- 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.
- geldanomycin
- Z3K3VJ16KU
- NSC 122750
- CHEBI:5292
- NSC212518
- RefChem:142823
- DTXCID5022691
- NSC122750
- MFCD00274570
- U 29135
- Geldanamycin from Streptomyces hygroscopicus
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