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TEGAFUR
SynDRA canonical compound SYN0001186 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | TYMS |
|---|
| Mechanism of action | Thymidylate synthase inhibitor |
|---|
| Indication | colorectal cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- TYMS
- DPYD
- CD44
- Candi TMP1
- TERT
- ABCC5
- ABCC11
- CYP19A1
- Tyms
- upp
Mechanisms of action (all sources)
- thymidylate synthase inhibitor
- TYMS INHIBITOR
- DNA synthesis inhibitor
- RNA synthesis inhibitor
- Candi TMP1 INHIBITOR
- DPYD INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- DRD2
- ACHE
- KDR
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KCNH2
- FLT1
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- MMP1
- MMP9
- NPY1R
- PTGS1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
- SIGMAR1
- PTPRC
- PTGS2
- PTAFR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antimetabolites
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Noxae
- Nucleic Acid Synthesis Inhibitors
- Nucleoside Metabolic Inhibitor
- Appetite Stimulants
- Central Nervous System Agents
- Central Nervous System Stimulants
- Immunologic Factors
- Immunosuppressive Agents
ATC classes
Cross-references
Synonyms
- ftorafur
- FT-207
- florafur
- futraful
- Atillon
- Coparogin
- Exonal
- Fental
- Franrose
- Ftorafur
- Fulaid
- Fulfeel
- Furafluor
- Furofutran
- Futraful
- Lamar
- Lifril
- Neberk
- Nitobanil
- Sinoflurol
- Sunfural
- Tefsiel c
- Tegafur-uracil
- Youfuding
- BMS-200604
- J356.722B
- MJF-12264
- NSC-148958
- Citofur
- Riol
- Tegafur component of s-1
- Tegafur component of teysuno
- Tegafur component of ts-1
- Uftoral
- Tegafur (Fluoropyrimidine)
- UFT
- Orzel
- UFUR
Reported adverse events
- Death
- Arthralgia
- Asthenia
- Constipation
- Cough
- Dyspepsia
- Lethargy
- Nausea
- Pyrexia
- Rash
- Stomatitis
- Vomiting
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