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APAFANT
SynDRA canonical compound SYN0001184 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Primary target(s) | PTAFR |
|---|
| Mechanism of action | Platelet activating factor receptor antagonist |
|---|
All known targets
Mechanisms of action (all sources)
- Platelet activating factor receptor antagonist
- PTAFR ANTAGONIST
- PTAFR MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADRB2
- ABCB1
- KCNH2
- MUTYH
- MPG
- MBD4
- MAPK1
- MAOA
- LCK
- HTR3A
- NEIL2
- HTR2B
- HTR2A
- HTR1B
- HTR1A
- HRH2
- HRH1
- NEIL1
- NR3C1
- GSK3B
- S1PR1
- TRIM24
- TDG
- SMUG1
- SLC6A4
- SLC6A3
- SLC6A2
- PTGS2
- OGG1
- PTGS1
- PDE4D
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- HDAC6
- GPR35
- ABL1
- ALOX15
- BRPF1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Fibrinolytic Agents
- Platelet Aggregation Inhibitors
Cross-references
Synonyms
- DE-081
- WEB-2086
- WEB-2086-BS
- WEB2086
- Web 2086
- Apafant [USAN:INN]
- Apafantum [INN-Latin]
- Apafanto [INN-Spanish]
- WEB 2086BS
- UNII-J613NI05SV
- WEB 2086 BS
- BRN 4302553
- C22H22ClN5O2S
- J613NI05SV
- CHEMBL280164
- NCGC00092377-03
- NCGC00092377-02
- Apafantum
- Apafanto
- DSSTox_CID_28900
- DSSTox_RID_83168
- DSSTox_GSID_48974
- 4-(3-(4-(o-Chlorophenyl)-9-methyl-6H-thieno(3,2-f)-s-triazolo(4,3-a)(1,4)diazepin-2-yl)propionyl)morpholine
- [3H]apafant
- Morpholine
- Apafant (ophthalmic formulation), Santen
- triazolodiazepine
- Apafant [INN]
- APAFANT [JAN]
- APAFANT [USAN]
- APAFANT [MI]
- APAFANT [MART.]
- DTXCID5028900
- Apafantum (INN-Latin)
- Apafanto (INN-Spanish)
- APAFANT (MART.)
- RefChem:558390
- CAS-105219-56-5
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