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DITOLYLGUANIDINE

SynDRA canonical compound SYN0001180 — structure-anchored drug synonym record

All known targets

• GRIN1
• GRIN2A
• GRIN2B
• SIGMAR1
• TMEM97

Mechanisms of action (all sources)

• TMEM97 AGONIST
• sigma receptor agonist
• SIGMAR1 AGONIST
• GRIN1 INHIBITOR
• GRIN2B INHIBITOR
• GRIN2A INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• EBP
• ALOX15
• KCNH2
• TDP1
• POLK
• PIN1
• PABPC1
• OPRM1
• OPRK1
• OPRD1
• HDAC6
• ALOX15B
• GNAS
• FEN1
• CYP3A4
• CYP2D6
• CYP2C9
• CYP2C19
• CYP1A2
• TSHR

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ACM1
• B2CL1
• CP2D6
• GLI3
• GRIN2C
• GRIN2D
• GRIN3A
• GRIN3B
• MCL1
• PABP1

Drug classes

• Anticonvulsants

Cross-references

• PubChem CID: 7333
• ChEMBL: CHEMBL282433
• ChEBI: 92585
• Wikipedia: Ditolylguanidine
• TTD: D02WJT
• LINCS BRD: BRD-K33459542

Synonyms

• 1,3-ditolylguanidine
• 1,3-Di-o-tolylguanidine
• Di-o-tolylguanidine
• DOTG
• Vulkacite DOTG
• Vulkacit DOTG
• Eveite DOTG
• Vulkacit dotg/C
• Nocceler DT
• Sanceler DT
• DOTG accelerator
• Soxinol DT
• Akrochem DOTG
• Vulcafor DOTG
• 1,3-Bis(o-tolyl)guanidine
• Guanidine, N,N'-bis(2-methylphenyl)-
• Diorthotolylguanidine
• 1,3-Di-o-tolyguanidine
• N,N'-Di-o-tolylguanidine
• Guanidine, 1,3-di-o-tolyl-
• USAF A-6598
• NSC 473
• CNS 1001
• N,N'-Di-o-tolueylguanidine
• UNII-LL2P01I17O
• 1,3-di-(2-tolyl)guanidine
• NSC 132023
• [3H]-di-o-tolylguanidine
• 1,3-Ditolylguanidine
• 1,2-bis(2-methylphenyl)guanidine
• N,N'-BIS(2-METHYLPHENYL)GUANIDINE
• Guanidine, 1,3-di(2-tolyl)-
• LL2P01I17O
• DTXCID206606
• 1,3-di-ortho-tolyl-guanidine
• RefChem:821755
• DTG
• 1,3-Di-2-tolylguanidine