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PYRAZINAMIDE
SynDRA canonical compound SYN0001171 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | FASN |
|---|
| Mechanism of action | Fatty acid synthase inhibitor |
|---|
| Indication | tuberculosis |
|---|
| Disease area | infectious disease |
|---|
All known targets
- FASN
- Bact inhA
- CA2
- CYP3A4
- CYP3A5
- cmaA1
- fas
- pncA
Mechanisms of action (all sources)
- Fatty acid synthase inhibitor
- Bact inhA INHIBITOR
- fas INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA3
- ESR2
- ESR1
- ACHE
- MC5R
- MAPK1
- MAPK14
- MAPK3
- MC3R
- MC4R
- MMP1
- MLNR
- LCK
- MMP9
- NPY1R
- NPY2R
- NR1I2
- MAOA
- KCNH2
- KDR
- NTSR1
- HTR7
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- NR3C1
- OPRD1
- GIPR
- OPRK1
- VDR
- USP1
- TSHR
- THRB
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antimycobacterial
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antitubercular Agents
ATC classes
- J04A · DRUGS FOR TREATMENT OF TUBERCULOSIS
Cross-references
Synonyms
- RIFATER
- pyrazinecarboxamide
- 2-pyrazinecarboxamide
- pyramizade
- alpha-pyrazinamide
- zinamide
- Pirazinamida
- .alpha.-pyrazinamide
- Aldinamid
- Aldinamide
- Eprazin
- Farmizina
- Isopas
- Novamid
- Pirazimida
- Pirazinamid
- Pyramizade
- Pyrazide
- Pyrazinamidum
- Pyrazine carboxylamide
- Rozide
- Unipyranamide
- Zinamide
- D-50
- MK-56
- NSC-14911
- Pirilene
- Pyrafat
- Pyrazinamide component of rifater
- Tebrazid
- Braccopiral
- Corsazinmid
- Dipimide
- Lynamide
- Pezetamid
- Pharozinamide
- Piraldina
Reported adverse events
- Gout
- Hepatotoxicity
- Hypersensitivity
- Thrombocytopenia
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