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SITAXENTAN
SynDRA canonical compound SYN0001164 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Primary target(s) | EDNRA |
|---|
| Mechanism of action | Endothelin receptor antagonist |
|---|
All known targets
Mechanisms of action (all sources)
- Endothelin receptor antagonist
- EDNRB ANTAGONIST
- Endothelin receptor, ET-A/ET-B antagonist
- EDNRA ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- ABCC2
- SLC6A4
- SLC6A3
- SLC6A2
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- HTR2B
- HTR1A
- HRH3
- HDAC6
- GALC
- F2
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- ADORA1
- ACHE
- ABCC4
- ABCC3
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- GAMT
- GNMT
- GPX1
- HLAB
- HNMT
- IFNB1
- NNMT
- PNMT
- PPARG
Drug classes
- Endothelin Receptor Antagonists
ATC classes
- C02K · OTHER ANTIHYPERTENSIVES
Cross-references
Synonyms
- thelin
- sitaxentan sodium
- sitaxsentan
- TBC11251
- TBC-11251
- Sitaxsentan
- IPI-1040
- PF-1228305
- Sitaxentan sodium
- Sitaxsentan sodium
- IPI 1040
- Sitaxentan (INN)
- N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((2-methyl-4,5-methylenedioxyphenyl)acetyl)thiophene-3-sulfonamide
- N-(4-Chloro-3-methyl-5-isoxazolyl)-2-((3,4-(methylenedioxy)-6-methylphenyl)acetyl)-3-thiophenesulfonamide
- N-(4-chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide
- TBC 11251
- J9QH779MEM
- DTXCID1031462
- sitaxentanum
- RefChem:886377
- C02KX03
- Sitaxentan [INN]
- Sitaxentan [USAN:INN]
- UNII-J9QH779MEM
- SITAXSENTAN [MI]
- Sitaxentan (USAN/INN)
- SITAXENTAN [USAN]
- SITAXENTAN [WHO-DD]
- SCHEMBL803344
- GTPL3950
- orb1708518
- SCHEMBL29372653
- CHEBI:135736
- PHWXUGHIIBDVKD-UHFFFAOYSA-N
- Tox21_113725
- BDBM50058126
- EBC-27142
- EX-A10944
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