METERGOLINE

SynDRA canonical compound SYN0001110 — structure-anchored drug synonym record

Clinical phase	Launched
Primary target(s)	HTR2A
Mechanism of action	Serotonin receptor antagonist
Indication	anxiety \| hyperprolactinemia \| seasonal affective disorder \| seasonal affective disorder, anxiety, hyperprolactinemia
Disease area	endocrinology \| neurology/psychiatry \| neurology/psychiatry, endocrinology

All known targets

HTR2A
HTR2B
HTR5A
HTR2C
HTR1F
HTR1E
HTR1D
HTR1B
HTR1A
HTR7
HTR6
DRD2

Mechanisms of action (all sources)

Dopamine receptor agonist
Serotonin receptor antagonist
dopamine receptor agonist, serotonin receptor antagonist
HTR2C ANTAGONIST
HTR1B ANTAGONIST
HTR1E ANTAGONIST
HTR1F ANTAGONIST
HTR5A ANTAGONIST
HTR1D ANTAGONIST
HTR2B ANTAGONIST
HTR2A ANTAGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

5HT1A
5HT1B
SYK
STK33
PRMT1
PPCEL
PAFA
MPI
MCL1
M4K2
KSYK
GPR32
GLI3
GEMI
CP3A7
CP2D6
CIB1
CAC1H
B2CL1
ACES
5HT7R
5HT6R
5HT5A
5HT2C
5HT2B
5HT2A
5HT1F
5HT1E
5HT1D
TPO

Drug classes

Dopamine Agents
Dopamine Agonists
Neurotransmitter Agents
Serotonin Agents
Serotonin Antagonists

ATC classes

G02C · OTHER GYNECOLOGICALS

Cross-references

PubChem CID: 28693
ChEMBL: CHEMBL1276418
DrugBank: DB13520
ChEBI: CHEBI:64216
KEGG: D07218
RxNorm: 6834
Wikipedia: Metergoline
TTD: D0UA0I
LINCS BRD: BRD-K56699285

Synonyms

Look up METERGOLINE in the interactive SynDRA portal →