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ROFECOXIB
SynDRA canonical compound SYN0001092 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
All known targets
- PTGS2
- CYP3A4
- ELN
- MT-CO2
- PTGER2
- PTGS1
- Ptgs1
- Ptgs2
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- F2
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- KCNH2
- HTR7
- HTR6
- HTR5A
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GIPR
- GHSR
- GCGR
- GABBR1
- FYN
- MMP1
- MMP9
- MT-CO1
- PTAFR
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Cross-references
Synonyms
- VIOXX
- vioxx
- ceeoxx
- M01AH02
- MK-0966
- MK-966
- MK0966
- NSC-720256
- NSC-758705
- TRM-201
- TRM201
- Vioxx
- Ceoxx
- Refecoxib
- Cahill May Roberts brand of rofecoxib
- MSD brand of rofecoxib
- Merck Frosst brandof rofecoxib
- Merck brand of rofecoxib
- Vioxx Dolor
- MK 0996
- Ceeoxx (TN)
- Ceoxx (TN)
- KS-1107
- Merck Sharp & Dhome brand of rofecoxib
- Vioxx (TN)
- Vioxx (trademark)
- Rofecoxib (JAN/USAN/INN)
- 3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone
- 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
- 4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone
- 4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone
- 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
- 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
- 4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
- MK 0966
- rofecoxibum
- 0QTW8Z7MCR
- NSC 720256
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