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NALTREXONE
SynDRA canonical compound SYN0001078 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | OPRM1 |
|---|
| Mechanism of action | Opioid receptor antagonist |
|---|
| Indication | abstinence from alcohol |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- OPRD1
- OPRK1
- OPRM1
- CHRNA7
- CYP2D6
- Chrna4
- Oprd1
- Oprk1
- Oprm1
- SIGMAR1
- Sigmar1
Mechanisms of action (all sources)
- Opioid receptor antagonist
- OPRK1 ANTAGONIST
- Opioid receptors; mu/kappa/delta antagonist
- OPRD1 ANTAGONIST
- OPRM1 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- MC4R
- OGG1
- OGFR
- NTHL1
- NR3C1
- NPY2R
- NPY1R
- NEIL2
- NEIL1
- MUTYH
- MRGPRX2
- MPG
- MMP9
- MMP1
- MC5R
- MC3R
- PDE3A
- MBD4
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- OPRL1
- PDE4A
- HRH1
- SMN1
- UNG
- UGT2B7
- UGT2B15
- UGT1A8
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Opioid Antagonists
- Alcohol Deterrents
- Central Nervous System Agents
- Narcotic Antagonists
- Peripheral Nervous System Agents
- Sensory System Agents
- Opioid Antagonist
ATC classes
- N07B · DRUGS USED IN ADDICTIVE DISORDERS
- ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
- OPIOIDS
Cross-references
Synonyms
- CONTRAVE
- Contrave
- EMBEDA
- NALTREXONE HYDROCHLORIDE
- REVIA
- ReVia
- TROXYCA ER
- VIVITROL
- Vivitrol
- cyclopropylmethylnoroxymorphone
- naltrel
- naltrexone hydrochloride
- naltrexone hydrochloride dihydrate
- naltrexone HCl
- Naltrexona
- EN-1639A FREE BASE
- EN-1639A [AS HYDROCHLORIDE]
- NSC-758439
- Celupan
- Trexal
- Depotrex
- Naltrel
- Vivitrex
- Naltrexone Depot
- IBS therapy, Pain Therapeutics
- Irritable bowel syndrome therapy, Pain Therapeutics
- PTI-901
- XR-NTX
- Naltrexone (sustained release), DAS
- Naltrexone (sustained release), elbion
- Naltrexone depot (injectable suspension), DrugAbuse Sciences
- Naltrexone depot (injectable suspension), elbion
- Opioid antagonists (irritable bowel syndrome), Pain Therapeutics
- Naltrexone (low-dose), Pain Therapeutics
- Naltrexone (polymer microcapsule depot, opioid addiction/alcohol dependency), Biotek
- Naltrexone (transdermal, alcohol/opioid dependence), Syntropharma
- Naltrexone (once-monthly controlled-release, Medisorb), Alkermes
Reported adverse events
- Depression
- Increased appetite
- Nasal congestion
- Abdominal pain
- Anxiety
- Arthralgia
- Dizziness
- Headache
- Hypertension
- Insomnia
- Nausea
- Rash
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