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LOFEXIDINE
SynDRA canonical compound SYN0001045 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA2A |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | opioid withdrawal |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ADRA2A
- ADRA2B
- ADRA2C
- Adra1a
- Adra1b
- Adra1d
- Adra2a
- Adra2b
- Adra2c
- HTR1A
- Nisch
- TADA2A
Mechanisms of action (all sources)
- Adrenergic receptor agonist
- ADRA2A AGONIST
- Adrenergic receptor alpha-2 agonist
- ADRA2C AGONIST
- ADRA2B AGONIST
- TADA2A AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- NR1I2
- ADORA1
- OPRD1
- HTR2B
- HTR2C
- HTR3A
- MAOA
- MC3R
- MLNR
- NPY1R
- NR3C1
- OPRK1
- ADORA2A
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- HTR2A
- HRH3
- HRH2
- HRH1
- ADORA3
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- AVPR2
- BDKRB2
- CCKAR
- CCKBR
- CHRM1
- CHRM2
- CHRM3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- CP1A2
- CP2D6
- CP3A4
- CP3A7
- ESRRA
- GLI3
- GPR151
Drug classes
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-2 Receptor Agonists
- Adrenergic alpha-Agonists
- Antihypertensive Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Narcotic Antagonists
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sensory System Agents
ATC classes
- N07B · DRUGS USED IN ADDICTIVE DISORDERS
Cross-references
Synonyms
- LOFEXIDINE HYDROCHLORIDE
- LUCEMYRA
- Lucemyra
- lofexidine hydrochloride
- (+/-)-Lofexidine
- lofexidine HCl
- lofexadine
- Lofexidina
- Britlofex
- Lofexidinum
- Britlofex (TN)
- Lofexidina [INN-Spanish]
- Lofexidine (INN)
- Lofexidine [INN:BAN]
- Lofexidinum [INN-Latin]
- UI82K0T627
- DTXCID703221
- CHEBI:51368
- RefChem:58519
- N07BC04
- Lofexidine (hydrochloride)
- Baq-168;MDL-14042
- LOFEXIDINE [INN]
- SR-01000763628
- UNII-UI82K0T627
- (+)-Lofexidine; (S)-(+)-Lofexidine
- LOFEXIDINE [MI]
- LOFEXIDINE [VANDF]
- LOFEXIDINE [WHO-DD]
- SCHEMBL48960
- GTPL9868
- orb1300016
- HY-B1052A
- KSMAGQUYOIHWFS-UHFFFAOYSA-N
- HMS2090C03
- HMS3713J03
- MSK15491
- Tox21_113963
Reported adverse events
- Bradycardia
- Dizziness
- Hypotension
- Insomnia
- Orthostatic hypotension
- Sedation
- Somnolence
- Syncope
- Tinnitus
- Depression
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