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PIOGLITAZONE
SynDRA canonical compound SYN0001035 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PPARG |
|---|
| Mechanism of action | PPAR receptor agonist |
|---|
| Indication | diabetes mellitus |
|---|
| Disease area | endocrinology |
|---|
All known targets
- PPARG
- TRPM3
- ABCB11
- MAOB
- Pparg
- Ppara
- PPARA
- Maob
- MAOA
- Abcb11
- INS
- Cisd1
Mechanisms of action (all sources)
- Insulin sensitizer
- PPAR receptor agonist
- PPARG AGONIST
- Peroxisome proliferator-activated receptor gamma agonist
- PPARG FULL AGONIST
- TRPM3 MODULATOR
- insulin sensitizer, ppar receptor agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- PPARD
- PTPN1
- TBXA2R
- ESR1
- ADRA2A
- MAPK1
- MAPK14
- MAPK3
- MC3R
- MC4R
- MLNR
- MC5R
- KDR
- MMP1
- MMP9
- NFE2L2
- NPY1R
- NPY2R
- LCK
- ABCC2
- KDM1A
- NR3C1
- HTR7
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GMNN
- KCNH2
- OPRK1
- NTSR1
- SLC29A1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- CP3A4
- CP3A7
- ESRRA
- GLI3
- NF2L2
- NTM1A
- NTMT1
- RXRA
Drug classes
- Peroxisome Proliferator-activated Receptor Activity
- Peroxisome Proliferator-activated Receptor alpha Agonists
- Peroxisome Proliferator-activated Receptor gamma Agonists
- Hypoglycemic Agents
- Peroxisome Proliferator Receptor alpha Agonist
- Peroxisome Proliferator Receptor gamma Agonist
- Thiazolidinedione
ATC classes
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- ACTOPLUS MET
- ACTOPLUS MET XR
- ACTOS
- Actoplus Met
- Actos
- DUETACT
- Duetact
- OSENI
- Oseni
- PIOGLITAZONE HYDROCHLORIDE
- PIOGLITAZONE HYDROCHLORIDE AND GLIMEPIRIDE
- PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE
- glustin
- sepioglin
- pioglitazone hydrochloride
- pioglitazone HCl
- Pioglitazona
- Zactos
- AD-4833
- U-72107
- Pioglitazonum
- Glustin
- Pioglitazonum [INN-Latin]
- Pioglitazona [INN-Spanish]
- Pioglitazone [INN:BAN]
- Pioglitazone [BAN:INN]
- AD 4833
- CHEBI:8228
- Pioglitazone (Actos)
- HSDB 7322
- Actos (TN)
- C19H20N2O3S
- U 72107A
- Actost
- Glustin (TN)
- HS-0047
- Pioglitazone (INN)
- U72,107A
Reported adverse events
- Lactic acidosis
- Lactic acid
- NGS
- Fracture
- Headache
- Myalgia
- Weight
- Sinusitis
- Pharyngitis
- Death
- Flatulence
- Acute coronary syndrome
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