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TERFENADINE
SynDRA canonical compound SYN0001030 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Primary target(s) | KCNH2 |
|---|
| Mechanism of action | Histamine receptor antagonist |
|---|
All known targets
- HRH1
- KCNH2
- KCNH1
- CYP2J2
- ABCB1
- TACR2
- SLC6A3
- SLC6A2
- HTR6
- HTR2C
- HTR2B
- HTR2A
Mechanisms of action (all sources)
- Histamine receptor antagonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
- CYP2J2 INHIBITOR
- KCNH1 MODULATOR
- KCNH2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- MC4R
- ADRB3
- CACNA1C
- SLC6A4
- MC3R
- CHRM2
- TACR1
- TBXA2R
- CYP3A4
- SCN5A
- ADRB2
- HTR1A
- ADRA2A
- HRH2
- NR3C1
- MMP9
- NPY1R
- NTSR1
- NPSR1
- OPRD1
- NPC1
- MTOR
- MPHOSPH8
- OPRK1
- NPY2R
- ABCB11
- MMP1
- MLNR
- MC5R
- PDE3A
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- HTT
- HTR7
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- IFNG
- M4K2
- MDM2
- MDM4
- MDR1
- MITF
- MLP3A
- MMP14
- NSD2
- S1PR4
- SMAD2
- SMAD3
- STK33
- SYK
- TPO
- TR10B
- KSYK
- IFNB1
- ANDR
- HLAB
- APAF
- BARD1
- BRCA1
- CAC1H
- CACNA1D
- CACNA1F
- CACNA1S
- CASP3
- CASP7
- CP19A
- CP2D6
- CP2J2
- EPAS1
- ESRRA
- GEMI
- TSHR
Drug classes
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Histamine H1 Antagonists, Non-Sedating
- Neurotransmitter Agents
- Histamine H1 Receptor Antagonists
- Histamine-1 Receptor Antagonist
- Anti-Allergic Agents
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
Cross-references
Synonyms
- ternadin
- racemic terfenadine
- seldane
- Terfenadina
- NSC-665802
- NSC-758627
- RMI-9918
- Antihistamine
- Histafen
- Histafen 120
- Seldane
- Terfenor
- Terfenor fte
- Terfex
- Terfinax 120
- Terfinax 60
- Triludan
- Triludan fte
- Aldaban
- Allerplus
- Cyater
- Hisfedin
- Rapidal
- Teldane
- Teldanex
- Terdin
- Terfedura
- Terfemundin
- Terfen
- Terfenadinum
- Terfenidine
- Ternadin
- Aliud Brand of Terfenadine
- Balkis Saft Spezial
- Bial Brand of Terfenadine
- Cantabria Brand of Terfenadine
- Ct-Arzneimittel Brand of Terfenadine
- Dolorgiet Brand of Terfenadine
Reported adverse events
- Cough
- Dizziness
- Fatigue
- Headache
- Pain in extremity
- Pain
- Dyspepsia
- Myalgia
- Nasopharyngitis
- Nausea
- Pyrexia
- Somnolence
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