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ROPINIROLE
SynDRA canonical compound SYN0001023 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DRD3 |
|---|
| Mechanism of action | Dopamine receptor agonist |
|---|
| Indication | Parkinson's Disease | restless leg syndrome |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- DRD3
- DRD4
- ADRA2A
- HTR2A
- ADRA2C
- DRD1
- DRD5
- ADRA2B
- HTR1A
- HTR2B
- HTR1D
Mechanisms of action (all sources)
- Dopamine receptor agonist
- DRD2 AGONIST
- D2-like dopamine receptor agonist
- DRD3 AGONIST
- DRD4 AGONIST
- DRD3 MODULATOR
- DRD2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADRA1A
- HRH3
- KCNH2
- OPRK1
- OPRM1
- ACHE
- MC3R
- NPY1R
- NEIL2
- NEIL1
- MUTYH
- MPG
- MLNR
- MC4R
- MAPK1
- MBD4
- NR1I2
- MAOA
- LMNA
- KDR
- KDM4E
- HTR3A
- HRH2
- HRH1
- HDAC6
- NPY2R
- NTHL1
- NR3C1
- GPR119
- TDG
- TBXA2R
- SMUG1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SAMHD1
- S1PR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Dopamine Agonists
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Dopamine Agents
- Neurotransmitter Agents
- Nonergot Dopamine Agonist
ATC classes
- N04B · DOPAMINERGIC AGENTS
Cross-references
Synonyms
- REQUIP
- REQUIP XL
- ROPINIROLE HYDROCHLORIDE
- ropinirol
- requip
- ropinirole hydrochloride
- ropinirole HCl
- Ropinirol
- NSC-758917
- SK&F-101468
- Ropitor
- Ropinirolum
- ReQuip CR
- ReQuip XL
- SKF 101468
- Adartrel (TN)
- Requip (TN)
- Ropark (TN)
- Ropinirol[INN-Spanish]
- Ropinirole (INN)
- Ropinirole [INN:BAN]
- Ropinirolum [INN-Latin]
- Ropitor (TN)
- SK&F 101468
- SK&F-101,468
- 4-[2-(Dipropylamino)ethyl]indoline-2-one
- 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
- Narapin
- NSC 758917
- SKF-101468
- CHEBI:8888
- DTXCID6025195
- Adartrel
- sk&f-101468a
- 4-(2-(dipropylamino)ethyl)-3H-indol-2-ol
- 4-[2-(dipropylamino)ethyl]-3H-indol-2-ol
- CLEVOR
- RefChem:57482
Reported adverse events
- Hallucination
- Hypersensitivity
- Nervousness
- Syncope
- Vomiting
- Amnesia
- Anxiety
- Arthralgia
- Arthritis
- Bronchitis
- Constipation
- Cough
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