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TRIMETREXATE
SynDRA canonical compound SYN0001014 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | DHFR |
|---|
| Mechanism of action | dihydrofolate reductase inhibitor |
|---|
All known targets
- DHFR
- DFR1
- Dhfr
- FPGS
- PDF
- dfrA17
- folA
Mechanisms of action (all sources)
- dihydrofolate reductase inhibitor
- PDF INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- DRD1
- SLC6A3
- PTGS1
- PDE4A
- OPRM1
- MAOA
- KCNH2
- DRD3
- HTR1A
- CHRM2
- CYP3A4
- USP1
- TDP1
- TBXA2R
- SLC6A4
- ADRA1A
- SLC6A2
- ADRA2A
- POLK
- PGR
- ALDH1A1
- PDE3A
- APEX1
- MAPT
- AR
- BLM
- HTR2B
- ADORA1
- HRH3
- HPGD
- F2
- ESR1
- EHMT2
- CHRM1
- VDR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- AHR
- TP53
- SYK
- RARA
- PRGR
- NSD2
- NF2L2
- MEN1
- KSYK
- KMT2A
- IFNB1
- G3P
- ESRRA
- DYR
- CREB1
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- ATXN2
- TSHR
Drug classes
- Anti-Infective Agents
- Antifungal Agents
- Antimetabolites
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Enzyme Inhibitors
- Folic Acid Antagonists
- Noxae
ATC classes
- P01A · AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
Cross-references
Synonyms
- NEUTREXIN
- trimetrexate hydrate
- trimetrexate glucuronate
- CI-898
- JB-11
- Trimetrexato
- NSC-249008
- TMQ
- Trimetrexatum
- Jb-11
- Trimetrexato [INN-Spanish]
- Trimetrexatum [INN-Latin]
- Trimetrexate (USAN/INN)
- Trimetrexate [USAN:BAN:INN]
- NSC 249008
- UPN4ITI8T4
- NSC249008
- NSC328564
- Trimexate
- Hydrate, Trimetrexate
- RefChem:899934
- DTXCID603714
- JB11
- P01AX07
- CI898
- Monohydrate, Monoacetate Trimetrexate
- CI 898
- JB 11
- Trimetrexate Hydrate
- HSDB 6545
- NCGC00161419-02
- UNII-UPN4ITI8T4
- Trimetrexate [USAN:INN:BAN]
- TRIMETREXATE [MI]
- TRIMETREXATE [INN]
- TRIMETREXATE [HSDB]
- TRIMETREXATE [USAN]
- SCHEMBL3983
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